PAROXETINE HYDROCHLORIDE

Paroxetine hydrochloride and paroxetine mesylate are antidepressant drugs and are called selective serotonin-reuptake inhibitors (SSRIs).

SSRIs efficiently inhibits neuronal serotonin reuptake. They have mild to zero effect on norepinephrine or dopamine reuptake. They do not affect dopamine D2 or histamine H1, ⍺- or β-adrenergic receptors.

Short-term usage inhibit SSRIs block serotonin reuptake and also increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors.

Uses

Paroxetine HCL is used in treating The following disorders:

Depression
Panic attacks
Obsessive-compulsive disorder (OCD)
Anxiety disorders
Post-traumatic stress disorder

Warnings

Do not give this drug to people with the following conditions:

Those using MAOIs
Concurrent use with thioridazine or pimozide

Side Effects

Paroxetine HCL may have the following side effects:

Somnolence
Insomnia
Headache
Dizziness
Decreased libido
Nausea
Xerostomia
Constipation
Diarrhoea
Ejaculatory disturbances
Weakness
Tremor
Diaphoresis
Vasodilation
Chest pain
Palpitations
Hypertension
Tachycardia
Nervousness
Anxiety
Agitation
Abnormal dreams
Impaired concentration
Yawning
Depersonalisation
Amnesia
Emotional liability
Vertigo
Confusion
Chills
Rash
Pruritus
Dysmenorrhoea
Anorexia
Decreased appetite
Dyspepsia
Flatulence
Abdominal pain
Appetite increased
Vomiting
Weight gain
Impotence
Urinary frequency
UTI
Paresthesia
Myalgia
Back pain
Myoclonus
Myopathy
Myasthenia
Arthralgia
Blurred vision
Tinnitus
Respiratory disorders
Pharyngitis
Sinusitis
Rhinitis
Infections

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Pregnancy and lactation

Interactions

Paroxetine HCL may interact with the following medicines:

Cyproheptadine
Phenytoin
Carbamazepine
Cimetidine
CYP2D6 inhibitors (example chlorpromazine, delavirdine, fluoxetine, miconazole, pergolide, quinidine, quinine, ritonavir, ropinirole)
Atomoxetine
Carvedilol
Clozapine
CYP2B6 substrates (example bupropion, promethazine, propofol, selegiline, sertraline)
CYP2D6 substrates (e.g. amphetamines, selected beta-blockers, dextromethorphan, fluoxetine, lidocaine, mirtazapine, nefazodone, risperidone, ritonavir, thioridazine, TCAs, venlafaxine)
Duloxetine
Glutamine
Mexilitine
Pimozide
Procyclidine
Propafenone
CYP2D6 prodrug substrates (example codeine, hydrocodone, oxycodone, tramadol)
Dextromethorphan
Haloperidol
Thioridazine
Beta-blockers
Other CNS depressants
Amphetamines
SSRIs
Meperidine
Nefazodone
Trazodone
Serotonin agonists
Sibutramine
Sympathomimetic
Tramadol
Venlafaxine
NSAIDs
Aspirin
Warfarin
Other drugs affecting coagulation
Amphetamines
Lithium
Loop diuretics
Selegiline
Nonselective MAOIs

Overdose & Brands

If you think you have used Paroxetine HCL more than the usual dosage, please seek medical help immediately.

Available Brands:

Xet 20
Seroxat