Major Interaction Do not take this combination
- Medications for depression (Antidepressant drugs) some of them are:
- fluoxetine (Prozac)
- paroxetine (Paxil)
- sertraline (Zoloft)
- amitriptyline (Elavil)
- clomipramine (Anafranil)
- imipramine (Tofranil)
- Medications for depression (MAOIs) some of them are phenelzine (Nardil) and tranylcypromine (Parnate)
Moderate Interaction Be cautious with this combination
- Dextromethorphan (Robitussin DM, and others)
- Medications for high blood pressure (ACE inhibitors), some of them are:
- captopril (Capoten)
- enalapril (Vasotec)
- lisinopril (Prinivil, Zestril)
- ramipril (Altace)
- Medications for high blood pressure (Calcium channel blockers), some of them are:
- nifedipine (Adalat, Procardia)
- verapamil (Calan, Isoptin, Verelan)
- diltiazem (Cardizem)
- isradipine (DynaCirc)
- felodipine (Plendil)
- amlodipine (Norvasc)
- Medications used to prevent seizures (Anticonvulsants), some of them are:
- phenobarbital
- primidone (Mysoline)
- valproic acid (Depakene)
- gabapentin (Neurontin)
- carbamazepine (Tegretol)
- phenytoin (Dilantin)
- Meperidine (Demerol)
- Methyldopa (Aldomet)
- Methylxanthines (aminophylline, caffeine, and theophylline)
- Muscle relaxants, some of them are:
- carisoprodol (Soma)
- pipecuronium (Arduan)
- orphenadrine (Banflex, Disipal)
- cyclobenzaprine
- gallamine (Flaxedil)
- atracurium (Tracrium)
- pancuronium (Pavulon)
- succinylcholine (Anectine)
- NSAIDs (Nonsteroidal anti-inflammatory drugs, some of them are:
- ibuprofen (Advil, Motrin, Nuprin, others)
- indomethacin (Indocin)
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- piroxicam (Feldene)
- aspirin
- Phenothiazines, some of them are:
- chlorpromazine (Thorazine)
- fluphenazine (Prolixin)
- trifluoperazine (Stelazine)
- thioridazine (Mellaril)
- Tramadol (Ultram)
- Water pills (Loop diuretics)
- Water pills (Thiazide diuretics), some of them are:
- chlorothiazide (Diuril)
- hydrochlorothiazide (HydroDIURIL, Esidrix)
- indapamide (Lozol)
- metolazone (Zaroxolyn)
- chlorthalidone (Hygroton)
Minor Interaction Be watchful with this combination
Dosing:
The following doses have been studied in scientific research:
BY MOUTH:
For acute manic episodes: 1.8 g or 20-30 mg per kg of lithium carbonate per day in 2-3 divided doses. Some healthcare providers begin therapy at 600-900 mg per day and gradually increase the dose.
For bipolar disorder and other psychiatric conditions: The usual adult dose is 900 mg to 1.2 g per day in 2-4 divided doses. 24-32 mEq of lithium citrate solution, given in 2-4 divided doses daily, has also been used. Doses usually should not exceed 2.4 g of lithium carbonate or 65 mEq lithium citrate daily. For children, 15-60 mg per kg (0.4-1.6 mEq per kg) per day in divided doses has been used.
Lithium may be given as a single daily dose, but is usually given in divided doses to lessen side effects.
Stopping lithium therapy suddenly increases the chance that symptoms of bipolar disorder will return. The dose of lithium should be reduced gradually over at least 14 days.
There is no recommended dietary allowance (RDA) for lithium. A provisional RDA of 1 mg per day for a 70 kg adult has been suggested.