COMMON BRAND NAME(S): Eldepryl
GENERIC NAME(S): SELEGILINE HCL
Description: Selegiline is a monoamine oxidase (MAO) , type B inhibitor. It is believed to prevent tyramine and other indirect acting sympathomimetics from displacing norepinephrine from adrenergic neurons. This mechanism helps to slow the progression of Parkinson’s disease.
Absorption: Approximately 10% of the drug is absorbed in the gastrointestinal tract
Distribution: Rapidly distributed throughout the body and crosses the blood-brain barrier.
Metabolism: Extensive hepatic first-pass effect
Excretion: Mainly as metabolites in the urine; about 15% is excreted via faeces. Elimination half-life: about 10 hr.