WARFARIN

Minor side effects (if these symptoms persist or worsen, inform your doctor)

• Nausea, loss of appetite, or stomach/abdominal.

Serious side effects (inform your doctor immediately)

• Serious bleeding.
  • unusual pain/swelling/discomfort, unusual/easy bruising, prolonged bleeding from cuts or gums, persistent/frequent nosebleeds, unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness/fainting, unusual or persistent tiredness/weakness, bloody/black/tarry stools, chest pain, shortness of breath, difficulty swallowing.
• Persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin.
• Severe skin/tissue damage that may require surgery or amputation if left untreated.
  • Painful/red/purplish patches on the skin (such as on the toe, breast, abdomen), change in the amount of urine, vision changes, confusion, slurred speech, weakness on one side of the body.

Severe allergic reactions are rare. Get immediate medical help if you notice the following:

• Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Precautions

• Inform your doctor.
  • Allergy to the medication or any allergies.
  • Medical History of blood disorders (such as anemia, hemophilia), bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), blood vessel disorders (such as aneurysms), recent major injury/surgery, liver disease, alcohol use, mental/mood disorders (including memory problems), frequent falls/injuries.

• May cause stomach bleeding. Limit alcoholic beverages.

• May cause heavy bleeding. To lower the chance of getting cut, bruised, or injured, use great caution with sharp objects like safety razors and nail cutters. Use an electric razor when shaving and a soft toothbrush when brushing your teeth. Avoid activities such as contact sports.

• Should not be used during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.

• Consult your doctor before breast-feeding as this medication passes into breast milk and although adverse effects are unlikely.

Interactions

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

• Products that may interact with this medication include:
  • capecitabine, imatinib, mifepristone, Aspirin, aspirin-like drugs (salicylates), and nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen, celecoxib), bromelains, coenzyme Q10, danshen, dong quai, fenugreek, garlic, ginkgo biloba, ginseng, and St. John’s wort.
• Laboratory tests that may be affected:
  • laboratory test to measure theophylline levels.

Overdose

• If overdose is suspected, contact a poison control center or emergency room immediately.
  • bloody/black/tarry stools, pink/dark urine, unusual/prolonged bleeding.

Notes: Do not share this medication with others.

Laboratory and/or medical tests (such as INR, complete blood count) must be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and as soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose. Keep a record of missed doses to give to your physician. Contact your physician if you miss 2 or more doses in a row.

Storage:

• Room temperature
• Do not expose to light and moisture
• Do not store in the bathroom
• Keep all medications away from pets and children

Brands

Available Brands

• Coumadin [ Taro ]
• Warik [ Ajanta Pharma Phil ]

Also marketed as

• Zyfarin [ Zydus Cadila ]