COMMON BRAND NAME(S): Zoloft
GENERIC NAME(S): SERTRALINE HCL
Description: Sertraline is an antidepressant under the serotonin selective reuptake inhibitor (SSRI) and blocks the 5-HT receptors resulting in increased serotonin concentrations leading to improvement of depression.
Absorption: Absorbed from the GI tract (oral), 4.5-8.5 hr after oral admin.
Distribution: Body tissues (wide), enters breast milk. Protein-binding: 98%.
Metabolism: Extensive hepatic first-pass metabolism
Excretion: Via urine and faeces (as metabolites)