COMMON BRAND NAME(S): Serzone
GENERIC NAME(S): NEFAZODONE HCL
Description: Nefazodone, a phenylpiperazine antidepressant
Absorption: Rapidly and completely absorbed but absolute bioavailability is variable and low (about 20%). Time to peak plasma concentration: 1 hr. Absorption delayed by food and bioavailability decreased by approx 20% (clinically not significant).
Distribution: Widely distributed including CNS, with small amounts distributed into breast milk. Volume of distribution: 0.22-0.87 L/kg. Protein binding: Extensively bound to human plasma proteins(>99%).
Metabolism: Undergoes extensive 1st pass metabolism to several metabolites, of which hydroxynefazodone and m-chlorophenylpiperazine, are pharmacologically active.
Excretion: Mainly as metabolites via the urine (about 55%) and the faeces (20-30%). Half-life: 2-4 hr.