Levosulpiride is a drug that is also a substituted benzamide. It has antidopaminergic and selective dopamine D2 receptor effects on both central and systemic levels. It is an atypical neuroleptic drug and a prokinetic agent that is used for gastroesophageal reflux disorders and irritable bowel syndrome. Also known as prokinetic agent that claims to have mood-elevating properties. In some countries like the United Kingdom and Europe, this is not a licensed drug, as it causes men to develop premature ejaculation. The drug is used in patients with nonspecific esophageal motility disorders. It is the levo-enantiomer of sulpiride, a well-known antiemetic, an antidyspeptic, an antipsychotic drug.
The said drug can relieve esophageal symptoms by promoting esophageal peristalsis and normalizing lower esophageal sphincter pressure (LESP). It is also useful in patients with nonspecific esophageal motility disorders (NEMD). Another study was also conducted to thirty patients with NEMD, who were administered 25 mg of levosulpiride for 2 weeks, where symptom assessments, esophageal manometry, blood biochemistry, and serum prolactin concentrations were evaluated before and after treatment. This drug was shown to relieve symptoms.
