Levosulpiride - Uses, Warnings,Precautions, Overdose and Brands


Levosulpiride is a drug that is also a substituted benzamide. It has antidopaminergic and selective dopamine D2 receptor effects on both central and systemic levels. It is an atypical neuroleptic drug and a prokinetic agent that is used for gastroesophageal reflux disorders and irritable bowel syndrome. Also known as prokinetic agent that claims to have mood-elevating properties. In some countries like the United Kingdom and Europe, this is not a licensed drug, as it causes men to develop premature ejaculation. The drug is used in patients with nonspecific esophageal motility disorders. It is the levo-enantiomer of sulpiride, a well-known antiemetic, an antidyspeptic, an antipsychotic drug.

The said drug can relieve esophageal symptoms by promoting esophageal peristalsis and normalizing lower esophageal sphincter pressure (LESP). It is also useful in patients with nonspecific esophageal motility disorders (NEMD). Another study was also conducted to thirty patients with NEMD, who were administered 25 mg of levosulpiride for 2 weeks, where symptom assessments, esophageal manometry, blood biochemistry, and serum prolactin concentrations were evaluated before and after treatment. This drug was shown to relieve symptoms.

Levosulpiride is used in the following conditions:

  • Gastroesophageal reflux disease
  • Irritable bowel syndrome
  • Dyspepsia
  • Congestive heart failure

Do not use Levosulpiride in people with the following conditions:

  • Pheochromocytoma
  • Epilepsy
  • Manic states
  • Hyperprolactinemia
  • Mammary dysplasia
  • Malignant mastopathies
  • Cardiac impairment
  • Gastrointestinal bleeding
  • Mechanical obstruction or perforation

Levosulpiride may have the following side effects:

  • Amenorrhea
  • Gynecomastia
  • Galactorrhea
  • Changes in libido
  • Neuroleptic malignant syndrome


Take extra caution in patients with the following medical conditions:

  • May impair ability to drive or operate machinery
  • Pregnancy
  • Lactation



Levosulpiride may interact with the following medicines:

  • Sucralfate
  • Aluminium- and magnesium-containing antacids
  • Anticholinergic agents
  • Narcotics and analgesics
  • Alcohol

If you think you have used Levosulpiride more than the usual dosage, please seek medical help immediately.


Available Brands:

  • Enliva
  • Dislep

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