Triprolidine is an antihistamine that works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

This medication is used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rashes; watery eyes; itchy eyes, nose, throat, skin; cough; runny nose; and sneezing. This medication may also be used in other conditions to be determined by your doctor.

Do not use this drug:

  • If you are allergic to any ingredient in Triprolidine
  • If you are taking Sodium Oxybate (GHB)

Common side effects may include:

  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Loss of Appetite
  • Constipation
  • Stomach Upset
  • Blurred Vision
  • Decreased Coordination
  • Dry Mouth, Nose or Throat

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include

  • Mental or Mood Changes (such as Hallucinations, Irritability, Nervousness)
  • Ringing in the Ears
  • Trouble Urinating
  • Easy Bruising or Bleeding
  • Fast or Irregular Heartbeat
  • Seizures
  • Severe Allergic Reactions

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to it; or if you have any other allergies.
  • If you are to undergo any surgery.
  • If you are pregnant or breastfeeding.
  • Your medical history, especially of:
    • Breathing Problems (such as Asthma, Emphysema)
    • A Certain Eye Problem (Glaucoma)
    • Heart Problems
    • High Blood Pressure
    • Liver Disease
    • Seizures
    • Stomach Problems (such as Ulcers, Blockage)
    • Overactive Thyroid (Hyperthyroidism)
    • Urination Problems (such as Trouble Urinating Due to Enlarged Prostate, Urinary Retention)



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Antihistamines Applied to the Skin (such as Diphenhydramine Cream, Ointment, Spray)
  • Opioid Pain or Cough Relievers (such as Codeine, Hydrocodone)
  • Alcohol
  • Drugs for Sleep or Anxiety (such as Alprazolam, Lorazepam, Zolpidem)
  • Muscle Relaxants (such as Carisoprodol, Cyclobenzaprine)
  • Other Antihistamines such as Cetirizine And Diphenhydramine

This medication may interfere with certain laboratory tests such as allergy skin test. Make sure laboratory personnel and all your doctors know you use this drug to avoid false results.

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Large Pupils
  • Flushing
  • Fever
  • Hallucinations
  • Weakness
  • Shaking (Tremor)
  • Muscle Twitching
  • Loss of Consciousness
  • Seizures

In children, excitement may occur first before loss of coordination, drowsiness, loss of consciousness, seizures.


Available brand/s:

  • Evazine
  • Iterax
  • Sedazine

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