Salmeterol + Fluticasone is a medication that is composed of a bronchodilator called salmeterol and a steroid, fluticasone. Salmeterol is a long acting beta 2-agonist that exerts its effects on the lung to bring about bronchodilation. Fluticasone is a corticosteroid that reduces inflammation associated with asthma.

This medicine is usually given as an inhalation.

Salmeterol + Fluticasone is used in the treatment of asthma and chronic obstructive pulmonary disease.

Salmeterol + Fluticasone should not be used in the treatment of status asthmaticus or other new attacks of asthma.

Salmeterol + Fluticasone can bring about the following side effects:

  • Mouth and throat candidiasis
  • Throat irritation
  • Hoarseness/dysphonia
  • Nasopharyngitis
  • Lower respiratory tract infections (e.g. pneumonia and bronchitis)
  • Hypokalaemia
  • Headache
  • Tremors
  • Palpitation
  • Muscle cramps
  • Cushing’s syndrome
  • Cushingoid features
  • Adrenal suppression
  • Retardation of growth in children and adolescents
  • Bone mineral density decrease
  • Cataract
  • Glaucoma

Paradoxical bronchospasm


Take extra caution in patients with the following medical conditions:

  • Pulmonary TB
  • Severe cardiovascular disorders
  • Heart rhythm abnormalities
  • Diabetes mellitus
  • Thyrotoxicosis
  • Hypokalaemia
  • Patients at risk of decreased bone mineral content (e.g. smoking, old age, sedentary lifestyle, poor nutrition, family history of osteoporosis or long term use of drugs that may decrease bone mass (e.g. anticonvulsants and corticosteroids)
  • Pregnancy
  • Lactation



Salmeterol + Fluticasone may interact with the following medicines:

  • CYP 3A4 inhibitors e.g ritonavir, ketoconazole, itraconazole
  • Beta -agonists

If you have used Salmeterol + Fluticasone more than the recommended doses, seek medical help immediately.


Available Brands:

  • Symbicort
  • Seretide

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