Pasireotide

Pasireotide is a drug used to treat acromegaly and Cushing’s disease. It is a cyclohexapeptide somatostatin analogue that attaches to somatostatin receptors to inhibit the secretion of ACTH. This brings about diminished cortisol, corticotropin and growth hormone levels.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Pasireotide is used in the following conditions:

Acromegaly
Cushing’s disease

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Pasireotide in people with the following conditions:

Severe hepatic impairment (Child-Pugh C).

Side Effects

Pasireotide may have the following side effects:

Bradycardia
QT prolongation
Cholelithiasis
Hyper/hypoglycemia
Diabetes mellitus
Hypocortisolism
Hypothyroidism
Elevated liver enzyme
Anemia
Atrioventricular block
Diarrhea
Nausea
Constipation
Vomiting
Abdominal pain
Abdominal distention
Fatigue
Weakness
Pain
Erythema
Hematoma
Hemorrhage
Pruritus
Influenza
Increased gamma-glutamyl transferase
Increased serum lipase and amylase
Prolonged prothrombin time
Elevated glycosylated Hb
Increased creatinine phosphokinase
Weight loss
Peripheral edema
Decreased appetite
Hypercholesterolemia
Hypokalemia
Adrenal insufficiency
Impaired glucose tolerance
Myalgia
Arthralgia
Back pain
Limb pain
Headache
Dizziness
Vertigo
Anxiety
Insomnia
Nasopharyngitis
Upper respiratory tract infection
Cough
Alopecia
Pruritus
Xeroderma
Hypo/hypertension

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Patient with diabetes mellitus
Pre-existing cardiac disease
Risk factors for bradycardia
High-grade heart block
Acute myocardial infarction
Congestive heart failure
Congenital long QTsyndrome
Heart failure
Unstable angina
Mild to moderate hepatic impairment
severe renal impairment or ESRD
Pregnancy
Lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Pasireotide may interact with the following medicines:

Metoprolol
Verapamil
Physostigmine
Quinidine
Amiodarone
Clarithromycin
Moxifloxacin
Chlorpromazine
Haloperidol
Terfenadine
Astemizole
Chloroquine
Lumefantrine
Ketoconazole
Ciclosporin
Bromocriptine

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If overdose is suspected, call your health care provider immediately.

Available Brands:

Signifor
Signifor LAR