PARACETAMOL + PENTAZOCINE

Pentazocine is an opioid analgesic with agonist/antagonist action. Paracetamol is a peripherally and centrally acting antipyretic and analgesic. The combination gives additive analgesic effects.

Uses

Paracetamol + Pentazocine is used in the relief of mild to moderate pain.

Warnings

Paracetamol + Pentazocine should not be given to patients with hypersensitivity to either component. It should also be avoided in raised intercranial pressure or head injury.

Side Effects

Paracetamol + Pentazocine can bring about side effects such as the following:

Nausea
Vomiting
Constipation
Anorexia
Diarrhea
Dizziness
Sedation
Disorientation
Euphoria
Headache
Visual blurring, rarely dysphoria
Sweating
Flushing
Rashes
Urticaria
Urinary retention
Anaphylactoid reaction
Drug abuse & dependence
Potentially Fatal: Hepatic necrosis (especially in chronic alcoholics)

Precautions

Precautions

Take precautions in patients with the following medical conditions:

Head injury
Other intracranial lesions or preexisting increase in intracranial pressure (impedes pupillary response required for neurological assessment)
Patients on opiate analgesics
Opioid dependence
Acute alcoholism
Compromised respiratory, cardiac, renal or hepatic functions
Epileptic patients
Pregnancy & lactation
Children
Heart disease with accompanying nausea or vomiting

Interactions

Paracetamol + Pentazocine may interact with the following medicines:

Anticoagulants
Alcohol & other CNS depressants

Overdose & Brands

Symptoms of overdose would be a combination of those observed with pentazocine overdose and paracetamol overdose. Overdose of Pentazocine may lead to anxiety, strange thoughts, hallucinations and nightmares.

Increased BP and tachycardia associated with marked respiratory depression may also occur. Acute paracetamol overdose may cause nausea, vomiting, anorexia and abdominal pain. Severe overdosage may lead to potentially fatal hepatic necrosis. Oxygen, IV fluids, vasopressors and other supportive measures involves in the treatment.

Available Brand:

Fortagesic