Naphazoline, an imidazoline derivative sympathomimetic with α-adrenergic activity, produces vasoconstriction. When applied topically to mucous membranes, it reduces swelling and congestion. It is often used in combination with antazoline, an ethylenediamine derivative antihistamine, in ophthalmic preparations. Antazoline may be used as the hydrochloride, phosphate, sulfate or mesilate salts in ophthalmic preprations, usually in a concentration of 0.5%.
Naphazoline is used in the treatment of ocular (eye) allergy.
Naphazoline should not be used in people with angle closure glaucoma.
A patient with diabetes or hypertension needs to be warned about a few drug interactions. Certain medications should be avoided in pregnant or breastfeeding women. A few drugs should be avoided by patients with hepatitis or cardiac diseases.
Naphazoline may bring about the following side effects:
Precautions
Take extra caution in the following conditions:
Rebound congestion may occur with prolonged use or overuse. Medical advice should be sought if there is ocular pain, vision changes, worsening of redness or irritation of the eye or if symptoms lasts > 72 hr. Remove contact lens before use.
Interactions
Naphazoline may interact with the following medicines:
If you think you may have used Naphazoline more than the usual recommended dose, seek medical help immediately.
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