MARPHAGE

Do not use Marphage in people with the following conditions:

• Hypersensitivity
• Severe kidney impairment: Metformin is primarily excreted by the kidneys, and impaired renal function can lead to the accumulation of metformin in the body, increasing the risk of lactic acidosis, a rare but serious condition. Therefore, metformin is contraindicated in individuals with severe kidney impairment or end-stage renal disease.
• Acute or chronic metabolic acidosis: Metformin can contribute to the development of lactic acidosis, a condition characterized by an excessive buildup of lactic acid in the blood. Therefore, metformin is contraindicated in individuals with acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Severe infection or dehydration: Conditions such as severe infection, severe dehydration, or any situation that may lead to tissue hypoxia (low oxygen levels) can increase the risk of lactic acidosis. In these situations, the use of metformin is contraindicated.
• Liver disease: Metformin is primarily eliminated through the liver, and impaired liver function can affect its clearance from the body. Although metformin is not contraindicated in individuals with liver disease, caution is advised, and dose adjustments may be necessary.

Please note that this list may not be exhaustive, and it is always best to consult with your healthcare provider for comprehensive information on contraindications and precautions associated with metformin or any other medication.

Marphage may have the following side effects:

• Gastrointestinal issues: The most common side effects of metformin are gastrointestinal in nature. They may include diarrhea, nausea, vomiting, abdominal discomfort, and a metallic taste in the mouth. These symptoms usually occur at the beginning of treatment and may improve over time or with dose adjustments.
• Hypoglycemia: Metformin alone does not typically cause low blood sugar levels (hypoglycemia). However, when used in combination with other diabetes medications that can lower blood sugar, such as insulin or sulfonylureas, the risk of hypoglycemia may increase.
• Vitamin B12 deficiency: Long-term use of metformin has been associated with decreased absorption of vitamin B12, which may lead to a deficiency. Regular monitoring of vitamin B12 levels and supplementation, if necessary, may be recommended.
• Lactic acidosis (rare): Lactic acidosis is a serious but rare side effect of metformin. It occurs when there is an excessive buildup of lactic acid in the blood. Symptoms may include weakness, muscle pain, difficulty breathing, irregular heartbeat, and dizziness. Lactic acidosis is more likely to occur in individuals with kidney or liver problems or those who consume excessive alcohol.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Kidney function: Metformin is primarily excreted by the kidneys, so it is important to monitor kidney function before starting metformin therapy and periodically thereafter. Individuals with moderate to severe kidney impairment or end-stage renal disease may require dosage adjustments or an alternative treatment option.
• Liver function: Metformin is primarily eliminated through the liver, and impaired liver function can affect its clearance from the body. While metformin is generally safe for individuals with liver disease, caution is advised, and regular liver function monitoring may be recommended.
• Heart and cardiovascular conditions: Metformin is generally considered safe for individuals with cardiovascular conditions. However, if you have a history of heart failure, heart attack, or any other significant cardiovascular condition, your healthcare provider may need to assess the risks and benefits of metformin therapy.
• Surgery and medical procedures: If you are scheduled for surgery or a medical procedure that requires fasting or contrast dye, it is important to inform your healthcare provider about your metformin use. In some cases, metformin may need to be temporarily discontinued to reduce the risk of lactic acidosis.
• Alcohol consumption: Excessive alcohol consumption can increase the risk of lactic acidosis when combined with metformin. It is generally recommended to limit alcohol intake or avoid it altogether while taking metformin.
• Pregnancy and breastfeeding: The use of metformin during pregnancy or while breastfeeding should be discussed with a healthcare provider. While there is some evidence supporting the use of metformin in certain situations, individual circumstances and risks should be carefully evaluated.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Marphage may interact with the following medicines:

• Oral contraceptives: Some studies suggest that certain oral contraceptives may increase blood sugar levels and reduce the effectiveness of metformin. Close monitoring of blood sugar levels may be necessary.
• Some antibiotics: Certain antibiotics, such as trimethoprim and fluoroquinolones, may increase the risk of high blood sugar levels when used concurrently with metformin. Regular monitoring of blood sugar levels is important in such cases.
• Medications for heart conditions: Some medications for heart conditions, such as beta-blockers and calcium channel blockers, may mask symptoms of low blood sugar levels. Regular monitoring of blood sugar levels is essential if you are taking both metformin and these medications.
• Diuretics: Diuretics can sometimes reduce the effectiveness of metformin by increasing the excretion of the drug. Regular monitoring of blood sugar levels and possible adjustments to the metformin dosage may be necessary.
• Alcohol: Excessive alcohol consumption can increase the risk of lactic acidosis when combined with metformin. It is generally recommended to limit alcohol intake or avoid it altogether while taking metformin.
• Contrast dye: If you are scheduled for a medical procedure that involves the use of contrast dye, it is important to inform your healthcare provider about your metformin use. In some cases, metformin may need to be temporarily discontinued to reduce the risk of lactic acidosis.
• Supplements and herbal products: Certain supplements and herbal products, such as St. John’s wort, may interact with metformin and affect blood sugar control. It is important to discuss any supplements or herbal products you are taking with your healthcare provider.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Marphage