LOPRAZOLAM - Watsons Health


Loprazolam belongs to a group of medicines called hypnotics that It works by acting on your brain to help you sleep.

This drug is used to treat sleeplessness (insomnia) but only in the short term, where the insomnia is severe, disabling or distressing.  This medicine has a calming effect and sometimes known as sedatives or sleeping pills.

Loprazolam should be used with caution in:

  • The elderly
  • Women who are pregnant or who are breastfeeding
  • Patients with long-term liver or kidney problems
  • Depression or anxiety with depression
  • Aggression towards self or others,
  • Respiratory diseases
  • Personality disorders, and a history of stroke

Common side effects of this drug include:

  • Headache
  • Feeling Sick (Nausea)
  • Daytime Sleepiness
  • Limp Or Weak Muscles
  • Blurring Of Vision
  • Dizziness
  • Lack Of Co-Ordination And Balance (Ataxia)
  • Confusion
  • Rash
  • Difficulty Passing Water (Urine)
  • Feeling Lightheaded
  • Feeling Faint
  • Memory Loss (Amnesia)
  • Addiction (Dependence)

Tell your doctor promptly if any of these effects persist or worsen. Also, call your doctor if you have any unusual problems while taking this medication.


Do not take this medicine and tell your doctor if:

  • You are allergic (hypersensitive) to Loprazolam Mesylate or any of the other ingredients of this medicine; or if you are allergic (hypersensitive) to other benzodiazepines such as nitrazepam or temazepam.
  • You have a problem that causes severe muscle weakness (myasthenia gravis)
  • Your lungs do not work properly
  • You have heart problems
  • You suffer from depression, anxiety or mental problems including
  • phobias and obsessive disorders
  • You have ever been addicted to alcohol
  • You have a problem where you stop breathing for short periods at night (sleep apnoea)



Drug interactions may interfere with how your medication works. Tell your doctor about all your medications and any you start or stop using during treatment with Loprazolam.

Interactions of this drug to the following may cause very serious or possibly fatal symptoms:

  • Sodium oxybate used to treat muscular weakness (cataplexy) associated with extreme sleepiness (narcolepsy).
  • Other tranquillisers or sleeping pills, or other such medicines that act on the brain and nerves
  • Antidepressants (e.g. tricyclic antidepressants, such as such as amitriptyline or clomipramine; mirtazapine)
  • General anaesthetics and painkillers (narcotic analgesics for moderate-to-severe pain, such as codeine, methadone, morphine, oxycodone, pethidine or tramadol)
  • Antihistamines (used for treating allergies) that cause drowsiness (e.g. chlorphenamine or promethazine)
  • Antibiotics (e.g. rifampicin)
  • Anti-virals (e.g. ritonavir).

Notify your doctor and pharmacist about all of your medications and health problems so they can check for any interactions with this medication.

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.


Available brand:

  • Loprazolam

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