Levosimendan - Uses, Warnings,Precautions, Overdose and Brands


Levosimendan is a cardiovascular drug that functions as an inotrope and a vasodilator with calcium-sensitizing effects. It is reliant on calcium levels in the body and sensitizes tropin C to calcium. It likewise opens ATP-sensitive potassium channels on the smooth muscles of the blood vessels, which then causes heart and blood vessel vasodilation. Opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle causes smooth muscle relaxation, which is a vasodilatory effect. An increased force of contraction, a decreased preload and decreased afterload are results of the combined inotropic and vasodilatory actions. The drug exerts a cardioprotective effect by opening mitochondrial (ATP)-sensitive potassium channels in cardiomyocytes. It is suggested as inotropic support in acutely decompensated severe congestive heart failure when conventional therapy is no longer effective, and in cases when inotropic support should be done appropriately. The use of levosimendan is contraindicated in patients with moderate to severe kidney impairment, severe liver impairment, severe ventricular filling or outflow obstruction, very low blood pressure, fast heart rate, and/or history of abnormal heart rhythm.

Levosimendan is used in the following conditions:

  • Congestive heart failure

Do not use Levosimendan in people with the following conditions:

  • History of torsade de pointes
  • Severe kidneyand liver impairment

Levosimendan may have the following side effects:

  • Headache
  • Dizziness
  • Hypotension
  • Ventricular tachycardia
  • Extrasystoles
  • Atrial fibrillation
  • Hypokalemia
  • Insomnia
  • Gastrointestinal disturbances
  • Anemia
  • Arrhythmias
  • Tachycardia
  • Atrial fibrillation with rapid ventricular response


Take extra caution in patients with the following medical conditions:

  • Hypotension
  • Tachycardia or with mechanical obstruction affecting ventricular filling or outflow
  • Ongoing heart ischemia or long QTc interval
  • Kidney and liver impairment



Levosimendan may interact with the following medicines:

  • Acetyldigoxin
  • Acebutolol
  • Agmatine
  • Adenosine

If you think you have used Levosimendan more than the usual dosage, please seek medical help immediately.


Available Brands:


Related Articles


Rilmenidine is an antihypertensive agent that is centrally-acting. It works by activating the central receptors of imidazoline and has an [...]


Quinapril and hydrochlorothiazide both decrease blood pressure via different but complementary mechanisms. Quinapril, a prodrug of quinaprilat, is an ACE [...]


Norethisterone has the usual effects of a progestogen and transforms the endometrium from the secretory to the proliferative process. It [...]