LERCANIDIPINE

Lercandipine should not be used in patients with the following medical conditions:

• Unstable angina pectoris
• Untreated heart failure
• Recent heart attack, within one month
• Severe liver and kidney impairment
• Pregnancy
• Lactation
• Concurrent use with ciclosporin and strong CYP3A4 inhibitors

Lercanidipine can give rise to side effects such as the following:

• Precordial pain or angina pectoris
• Hypotension
• Fatigue
• Headache
• Dizziness
• Palpitations
• Peripheral edema
• Tachycardia
• Chest pain
• Orthostatic hypotension
• Vasodilatory effect
• Abdominal pain
• Nausea
• Dyspepsia
• Diarrhea
• Constipation
• Gingival hyperplasia
• Tinnitus
• Increased liver enzyme
• Polyuria
• Nocturia
• Muscle weakness
• Flushing
• Rash
• Itch

Precautions

Take extra precautions in people with the following conditions:

• Patients with porphyria
• Myasthenia-like neuromuscular disease
• Cardiogenic shock
• Systolic heart failure
• Aortic stenosis
• Sick sinus syndrome (if pacemaker is not in position)
• Ischemic heart disease
• Mild to moderate kidney and liver impairment

Interactions

Lercanidipine may interact with the following medicines:

• CYP3A4 inducers (example carbamazepine, phenytoin)
• β-blockers (example metoprolol)
• Ciclosporin and strong CYP3A4 inhibitors (example ketoconazole, ritonavir)

Symptoms of Lercanidipine overdose include the following:

• Severe hypotension and reflex tachycardia
• Cardiogenic shock
• Severe heart attack
• Bradycardia and loss of consciousness
• Drowsiness
• Emesis
• Mild kidney failure

Seek medical help immediately.

Available Brands:

• Zanidip