Lercanidipine - Uses Warnings Side Effects Precautions Overdose & Brands

LERCANIDIPINE

Bivalirudin

Lercanidipine is a medicine that belongs to a class of drugs known as dihydropyridine calcium channel blockers. It inhibits calcium influx in the heart and smooth muscles, further causing relaxation of vascular smooth muscle and lowering blood pressure.

Lercanidipine is used in the treatment of hypertension

Lercandipine should not be used in patients with the following medical conditions:

  • Unstable angina pectoris
  • Untreated heart failure
  • Recent heart attack, within one month
  • Severe liver and kidney impairment
  • Pregnancy
  • Lactation
  • Concurrent use with ciclosporin and strong CYP3A4 inhibitors

Lercanidipine can give rise to side effects such as the following:

  • Precordial pain or angina pectoris
  • Hypotension
  • Fatigue
  • Headache
  • Dizziness
  • Palpitations
  • Peripheral edema
  • Tachycardia
  • Chest pain
  • Orthostatic hypotension
  • Vasodilatory effect
  • Abdominal pain
  • Nausea
  • Dyspepsia
  • Diarrhea
  • Constipation
  • Gingival hyperplasia
  • Tinnitus
  • Increased liver enzyme
  • Polyuria
  • Nocturia
  • Muscle weakness
  • Flushing
  • Rash
  • Itch

Precautions

Take extra precautions in people with the following conditions:

  • Patients with porphyria
  • Myasthenia-like neuromuscular disease
  • Cardiogenic shock
  • Systolic heart failure
  • Aortic stenosis
  • Sick sinus syndrome (if pacemaker is not in position)
  • Ischemic heart disease
  • Mild to moderate kidney and liver impairment

 

Interactions

Lercanidipine may interact with the following medicines:

  • CYP3A4 inducers (example carbamazepine, phenytoin)
  • β-blockers (example metoprolol)
  • Ciclosporin and strong CYP3A4 inhibitors (example ketoconazole, ritonavir)

Symptoms of Lercanidipine overdose include the following:

  • Severe hypotension and reflex tachycardia
  • Cardiogenic shock
  • Severe heart attack
  • Bradycardia and loss of consciousness
  • Drowsiness
  • Emesis
  • Mild kidney failure

Seek medical help immediately.

Available Brands:

  • Zanidip

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