HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

IMATERO 100/IMATERO 400

Imatero 100/Imatero 400 is used in the following conditions:

  • Chronic Myeloid Leukemia (CML): Imatinib is a first-line treatment for chronic phase chronic myeloid leukemia (CML). It works by inhibiting the activity of the BCR-ABL tyrosine kinase, which is responsible for the abnormal growth and division of cancer cells in CML.
  • Acute Lymphoblastic Leukemia (ALL): Imatinib is also used in combination with chemotherapy to treat Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) in adults and children.
  • Gastrointestinal Stromal Tumors (GIST): Imatinib is considered the standard treatment for unresectable or metastatic gastrointestinal stromal tumors (GIST). It targets and blocks the activity of certain tyrosine kinases, including KIT and PDGFRA, which play a role in the growth and survival of GIST cells.
  • Dermatofibrosarcoma Protuberans (DFSP): Imatinib is approved for the treatment of dermatofibrosarcoma protuberans (DFSP) that cannot be surgically removed or has metastasized. It inhibits the activity of the platelet-derived growth factor receptor (PDGFR), which is involved in the development of DFSP.
  • Systemic Mastocytosis: Imatinib may be used in the treatment of systemic mastocytosis, a rare disorder characterized by the abnormal accumulation of mast cells in various organs. It can help reduce symptoms and improve quality of life in certain cases.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Imatero 100/Imatero 400 in people with the following conditions:

  • Hypersensitivity: Imatinib is contraindicated in individuals who have a known hypersensitivity or allergy to imatinib or any of its components. Allergic reactions can range from mild skin rash to severe symptoms like difficulty breathing or swelling of the face, lips, or throat.
  • Pregnancy: Imatinib can potentially harm the developing fetus. Therefore, it is contraindicated during pregnancy. If you are planning to become pregnant or suspect that you may be pregnant, it is important to inform your healthcare provider.
  • Breastfeeding: Imatinib may be excreted in breast milk and could potentially harm a nursing infant. Breastfeeding should be avoided during treatment with imatinib.
  • Severe liver impairment: Imatinib is metabolized by the liver, so individuals with severe liver impairment may have difficulty processing the medication. In such cases, the use of imatinib should be approached with caution or contraindicated altogether, depending on the severity of liver dysfunction.
  • Severe renal impairment: Imatinib and its metabolites are excreted through the kidneys. Individuals with severe renal impairment may experience reduced clearance of the drug, leading to an increased risk of adverse effects. Dose adjustments or alternative treatment options may be necessary.

Imatero 100/Imatero 400 may have the following side effects:

  • Gastrointestinal issues: Common side effects include nausea, vomiting, diarrhea, and abdominal pain. These symptoms are usually mild to moderate and can be managed with dietary changes, medication adjustments, or supportive care.
  • Fatigue: Many individuals report feeling tired or fatigued while taking imatinib. It’s important to get enough rest and engage in activities that support your overall well-being.
  • Skin problems: Imatinib can cause skin rashes, dryness, itching, or changes in skin color. These side effects are typically mild and can be managed with moisturizers or other topical treatments.
  • Edema: Some people may experience swelling or fluid retention, particularly in the legs and feet. It’s important to monitor and report any significant or persistent swelling to your healthcare provider.
  • Muscle cramps and pain: Imatinib may cause muscle cramps or musculoskeletal pain. Stretching exercises, staying hydrated, and pain medications as advised by your healthcare provider can help alleviate these symptoms.
  • Blood disorders: Imatinib can affect blood cell counts, leading to anemia (low red blood cells), thrombocytopenia (low platelets), or neutropenia (low white blood cells). Regular blood tests will be conducted to monitor these levels.
  • Liver and kidney problems: Imatinib may cause liver enzyme elevations or changes in kidney function. Regular monitoring of liver and kidney function is typically performed during treatment.
  • Other side effects: Less common side effects may include headaches, dizziness, fluid retention around the eyes, weight gain, and changes in taste.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Pregnancy and breastfeeding: Imatinib can potentially harm the developing fetus, so it is generally not recommended during pregnancy. If you are planning to become pregnant or suspect that you may be pregnant, it is important to inform your healthcare provider. Imatinib may also be excreted in breast milk and could potentially harm a nursing infant, so breastfeeding should be avoided during treatment.
  • Liver and kidney function: Imatinib is metabolized in the liver and excreted through the kidneys. If you have liver or kidney problems, your healthcare provider may need to adjust the dosage or monitor your liver and kidney function more closely.
  • Cardiovascular issues: Imatinib may cause fluid retention, which can exacerbate existing cardiovascular conditions. If you have a history of heart or blood vessel problems, such as heart failure or arrhythmias, it’s important to discuss this with your healthcare provider.
  • Bleeding disorders: Imatinib can increase the risk of bleeding. If you have a bleeding disorder or are taking medications that thin the blood, such as anticoagulants, it’s important to inform your healthcare provider.
  • Immunizations: While taking imatinib, live vaccines may be contraindicated. It’s important to discuss any upcoming immunizations with your healthcare provider to determine the best course of action.
  • Driving and operating machinery: Imatinib can cause dizziness or fatigue. If you experience these side effects, it’s important to avoid driving or operating machinery until you know how the medication affects you.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Imatero 100/Imatero 400 may interact with the following medicines:

  • Strong CYP3A4 inhibitors: Imatinib is metabolized by the enzyme CYP3A4. Drugs that inhibit this enzyme can increase the levels of imatinib in the body, potentially leading to increased side effects. Examples of strong CYP3A4 inhibitors include ketoconazole, itraconazole, clarithromycin, and grapefruit juice.
  • Strong CYP3A4 inducers: Conversely, drugs that induce the CYP3A4 enzyme can decrease the levels of imatinib in the body, potentially reducing its effectiveness. Examples of strong CYP3A4 inducers include rifampin, phenytoin, carbamazepine, and St. John’s wort.
  • Anticoagulants: Imatinib may increase the risk of bleeding. When taken with anticoagulant medications such as warfarin or aspirin, the risk of bleeding may be further increased. Close monitoring of clotting parameters is important if these medications are used together.
  • Acid-reducing agents: Medications that reduce stomach acid, such as proton pump inhibitors (PPIs) and H2 blockers, can decrease the absorption of imatinib. It is generally recommended to take imatinib on an empty stomach, at least two hours before or after taking acid-reducing agents.
  • QT-prolonging drugs: Imatinib can prolong the QT interval, which can increase the risk of abnormal heart rhythms. Taking imatinib with other medications that also prolong the QT interval, such as certain antiarrhythmics or antipsychotics, may further increase this risk.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

  • Imatero 100/Imatero 400

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