GLIBENCLAMIDE + METFORMIN

Glibenclamide + Metformin should not be given in patients with the following conditions:

• Diabetic ketoacidosis or diabetic pre-coma
• Acute conditions which may alter renal function (e.g. dehydration, severe infection, shock)
• Acute or chronic disease which may cause tissue hypoxia (e.g. cardiac or resp failure, recent MI, acute significant blood loss, sepsis, gangrene)
• Major surgery
• Porphyria
• Acute alcohol intoxication/alcoholism
• Renal (CrCl <60 mL/min) or hepatic impairment
• Lactation
• Concomitant use with bosentan, miconazole and intravascular administration of iodinated contrast materials

Glibenclamide + Metformin may have the following side effects:

• Hypoglycaemia
• Haemolytic anaemia
• Weight gain
• Upper respiratory infection
• Diarrhoea
• Headache
• Nausea and vomiting
• Abdominal pain
• Dizziness
• Lactic acidosis

Precautions

Take precautions in people with the following conditions:

• Impaired adrenal and/or pituitary function
• G6PD deficiency
• Heart failure
• Pregnancy

Interactions

Glibenclamide + Metformin may interact with the following medicines:

• Thiazides and other diuretics
• Corticosteroids
• Phenothiazines
• Thyroid products
• Estrogen
• Oral contraceptives
• Phenytoin
• Nicotinic acid
• Sympathomimetics
• Calcium channel blockers
• Isoniazid
• NSAIDs and other highly protein bound drugs
• Salicylates
• Sulfonamides
• Chloramphenicol
• Probenecid
• Coumarins
• MAOIs
• β-blockers
• Colesevelam
• Furosemide
• Nifedipine
• Cimetidine
• Bosentan
• Miconazole

Symptoms of overdose include:

• Mild to severe hypoglycaemia which may lead to hypoglycaemic coma (glibenclamide)
• Lactic acidosis (metformin)

Seek medical help immediately.

Available Brands:

Aviglen-forte, Aviglen MF, Ben-Q-Met, Ben-Q-Met Forte, Ben-Q-Met LS, Benclamet, Benclamet Forte, Benformin, Benformin HS