FOSFOMYCIN

Fosfomycin inhibits the first step of bacterial cell wall production within the cell. It causes a bactericidal impact on the propagating pathogen by inactivating pyruvyl transferase, an enzyme required for the formation of bacterial cell walls.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Uses

Fosfomycin is used in the following conditions:

Bone and joint infections
Complicated urinary tract infections
Hospital-acquired pneumonia
Osteomyelitis
Bacterial meningitis
Acute uncomplicated cystitis in women
Prophylaxis of urinary tract infections

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Fosfomycin in people with the following conditions:

Hypersensitivity
Oral: Severe renal impairment (creatinine clearance less than 10 mL/min)
Patient undergoing hemodialysis

Side Effects

Fosfomycin may have the following side effects:

Hepatic injury (including steatosis)
Hepatitis
Fungal or bacterial superinfection (prolonged use)
Hypernatremia (IV)
Hypokalemia (IV)
Neutropenia
Agranulocytosis
Diarrhea
Nausea
Abdominal pain
Dyspepsia
Vomiting
Dysgeusia (IV)
Injection site phlebitis
Asthenia (IV)
Headache, dizziness
Vulvovaginitis (oral)
Erythematous eruption (IV)

Potentially Fatal:

Hypersensitivity reactions (including anaphylaxis)
Anaphylactic shock
Clostridium difficile-associated diarrhea
Pseudomembranous colitis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Patient with cardiac insufficiency
Hypertension
Hyperaldosteronism
Hypernatremia
Pulmonary oedema (IV)
Pyelonephritis or perinephric abscess (oral)
Renal impairment or hepatic cirrhosis (IV)
Premature neonates
Neonates (IV)
Children (IV or oral [when used in acute uncomplicated cystitis])
Pregnancy
Lactation

Prior to taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions to the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Fosfomycin may interact with the following medicines:

Metoclopramide
Bethanechol
Cisapride
Domperidone
Laxatives

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms:

Oral:

Vestibular loss
Impaired hearing
Metallic taste
Generalised decrease in perception of taste

IV:

Hypotonia
Electrolyte disturbance
Somnolence
Thrombocytopenia
Hypoprothrombinemia

If an overdose is suspected, call your health care provider immediately.

Available brands:

Monurol