HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

FOSFOMYCIN

Fosfomycin inhibits the first step of bacterial cell wall production within the cell. It causes a bactericidal impact on the propagating pathogen by inactivating pyruvyl transferase, an enzyme required for the formation of bacterial cell walls.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Fosfomycin is used in the following conditions:

  • Bone and joint infections
  • Complicated urinary tract infections
  • Hospital-acquired pneumonia
  • Osteomyelitis
  • Bacterial meningitis
  • Acute uncomplicated cystitis in women
  • Prophylaxis of urinary tract infections

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Fosfomycin in people with the following conditions:

  • Hypersensitivity
  • Oral: Severe renal impairment (creatinine clearance less than 10 mL/min)
  • Patient undergoing hemodialysis

Fosfomycin may have the following side effects:

  • Hepatic injury (including steatosis)
  • Hepatitis
  • Fungal or bacterial superinfection (prolonged use) 
  • Hypernatremia (IV)
  • Hypokalemia (IV)
  • Neutropenia
  • Agranulocytosis
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Dyspepsia
  • Vomiting
  • Dysgeusia (IV)
  • Injection site phlebitis
  • Asthenia (IV)
  • Headache, dizziness
  • Vulvovaginitis (oral)
  • Erythematous eruption (IV)

Potentially Fatal: 

  • Hypersensitivity reactions (including anaphylaxis)
  • Anaphylactic shock
  • Clostridium difficile-associated diarrhea
  • Pseudomembranous colitis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with cardiac insufficiency
  • Hypertension
  • Hyperaldosteronism
  • Hypernatremia
  • Pulmonary oedema (IV)
  • Pyelonephritis or perinephric abscess (oral)
  • Renal impairment or hepatic cirrhosis (IV)
  • Premature neonates
  • Neonates (IV)
  • Children (IV or oral [when used in acute uncomplicated cystitis])
  • Pregnancy
  • Lactation

Prior to taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions to the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Fosfomycin may interact with the following medicines:

  • Metoclopramide
  • Bethanechol
  • Cisapride
  • Domperidone
  • Laxatives

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms: 

Oral: 

  • Vestibular loss
  • Impaired hearing
  • Metallic taste
  • Generalised decrease in perception of taste

IV: 

  • Hypotonia
  • Electrolyte disturbance
  • Somnolence
  • Thrombocytopenia
  • Hypoprothrombinemia

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Monurol

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