ERGOMETRINE

Bivalirudin

Ergometrine is a drug that causes contractions of the muscles in the uterus. At low doses, it can increase the frequency and amplitude of contractions while at higher doses, it increases the basal tone of the uterus. Ergometrine also gives rise to vasoconstriction of peripheral and cerebral blood vessels.

Ergometrine is used in the active management of the third stage of labor. It is also used in the treatment and prophylaxis of postpartum hemorrhage as well as of excessive uterine bleeding.

Ergometrine should not be given to patients with the following medical conditions:

  • Pregnancy, 1st and 2nd stage of labor
  • Patients with preeclampsia
  • Eclampsia or threatened spontaneous abortion
  • Porphyria

Ergometrine may give rise to the following side effects:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Headache
  • Dizziness
  • Tinnitus
  • Chest pain
  • Palpitation
  • Bradycardia
  • Transient hypertension and other cardiac arrhythmias
  • Dyspnea
  • Rashes
  • Shock
  • Heart attack
  • Pulmonary edema

Special precautions should be observed in people with the following conditions:

  • Breech and abnormal fetal presentation
  • Hypertension
  • Chronic anemia
  • Liver disease
  • Kidney disease
  • Heart disease
  • Toxemia
  • Lactation
  • Hypocalcemia

 

Interactions

Ergometrine may interact with the following medicines:

  • Halothane
  • Prostaglandins
  • Oxytocin
  • CYP3A4 inhibitors
  • Sympathomimetics and other vasoconstrictors

Ergometrine overdose may give rise to the following signs and symptoms:

  • Peripheral vasoconstriction
  • Encephalopathy
  • Convulsions
  • Respiratory failure
  • Acute renal failure and temporary lactose intolerance

Seek medical help immediately.

Available Brands:

Hemergin, Metherspan, Metherspan, Urgotin

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