Indications:
This medication is used to treat anemia (low red blood cell count) in people with long-term serious kidney disease (chronic kidney failure), people receiving zidovudine to treat HIV, and people receiving chemotherapy for certain types of cancer (non-myeloid cancers).
It may also be used in anemic patients to reduce the need for blood transfusions before certain planned surgeries that have a high risk of blood loss (usually combined with the “blood thinner” warfarin).
Contraindications:
Should not be given to patients with:
- Uncontrolled hypertension.
- Known hypersensitivity to mammalian cell-derived products.
- Known hypersensitivity to Albumin (Human).
How to use epoetin alfa injection
ADULTS:
Anemia Associated with Zidovudine
Initial: 100 units/kg subcutaneously or IV 3 times a week.
Anemia Associated with Chemotherapy
Initial: 150 units/kg subcutaneously 3 times weekly or 40,000 units subcutaneously once weekly until completion of chemotherapy course.
Anemia Associated with Chronic Renal Failure
50 to 100 units/kg subcutaneously or IV 3 times weekly.
The intravenous route is recommended for patients on hemodialysis.
Anemia Prior to Surgery
In patients with hemoglobin greater than 10 to less than or equal to 13 g/dL scheduled to undergo elective, noncardiac, nonvascular surgery to reduce the need for allogenic blood transfusions: 300 units/kg/day subcutaneously for 10 days before and on the day of surgery, and 4 days after surgery for a total of 14 days of epoetin therapy.
Alternate dosage schedule: 600 units/kg subcutaneously in once weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.
Pediatric:
Anemia Associated with Zidovudine
Infants and Children 8 months to 17 years: Limited data available; doses ranging from 50 to 400 units/kg 2 to 3 times/week have been reported. If patients have not responded satisfactorily to a dose of 300 units/kg 3 times weekly, it is unlikely that they will respond to higher doses.
Anemia Associated with Chemotherapy
Infants and Children 6 months to 18 years: Doses ranging from 25 to 300 units/kg 3 to 7 times a week have been reported.
Manufacturer’s recommendation: Starting dose: Using intravenous administration only: 600 units/kg weekly (not to exceed 40,000 units/week); may increase to 900 units/kg weekly (not to exceed 60,000 units/week).
Anemia Associated with Chronic Renal Failure
Starting dose for infants, children and adolescents: 50 units/kg, intravenously or subcutaneously, 3 times weekly. Increase dose by 25% if hemoglobin is less than 10 g/dL and has not increased by 1 g/dL after 4 weeks of therapy or if hemoglobin decreases below 10 g/dL. In patients on hemodialysis, the intravenous route is recommended.
Anemia
The safety and efficacy of epoetin alfa in children have not been established. However, the use of epoetin alfa may be appropriate in some situations.
Anemia of prematurity: Dosing range: 500 to 1250 units/kg/week divided into 2 to 5 doses for 10 doses; commonly used dose: 250 units/kg/dose 3 times weekly; supplement with oral iron therapy 3 to 8 mg/kg/day.