DIMETHYL FUMARATE

Dimethyl fumarate is a drug that belongs to a type of drugs known as fumaric acid derivatives. This drug has anti-inflammatory properties and is said to affect the body’s immune system. It reduces immune cell activation and decreases the release of inflammatory substances. It also affects the way cells and tissues are protected against stress.

Uses

Dimethyl fumarate is used in the treatment of multiple sclerosis, moderate to severe plaque psoriasis and other inflammatory conditions.

Warnings

Dimethyl fumarate should not be used by people with hypersensitivity to it.

Side Effects

Dimethyl fumarate may give rise to the following side effects:

Anaphylaxis
Angioedema
Leucopenia
Lymphopenia
Opportunistic infections
Liver injury
Flushing
Gastrointestinal disturbances such as diarrhoea, abdominal distension, abdominal pain, nausea, vomiting, dyspepsia, constipation, abdominal discomfort, flatulence
Proteinuria
Ketonuria
Albuminuria
Headache
Numbness
Fatigue
Asthenia
Decreased appetite
Increased liver enzymes
Hot flush
Eosinophilia
Leukocytosis
Redness
Burning sensation of the skin
Itching skin
Rash
Progressive multifocal leukoencephalopathy

Precautions

Precautions

Dimethyl fumarate should be used with caution in patients with the following conditions:

Severe gastrointestinal disorders
Serious infections
Severe kidney and liver impairment
Pregnancy
Breastfeeding

Interactions

Dimethyl fumarate may have interactions with the following medications:

Methotrexate
Ciclosporin
Aminoglycosides
Lithium
Live vaccines

Overdose & Brands

If you think you have used Dimethyl fumarate more than the recommended dose, seek medical help immediately.

Available Brand/s:

Tecfidera