DELAPRIL

Delapril is a drug that inhibits angiotensin converting enzyme from angiotensin I to angiotensin II, which is a potent vasoconstrictor. This results to increase in plasma renin activity and reduction in aldosterone.  Aldosterone is a hormone that causes water and sodium retention. It may also inhibit the degradation of bradykinin.

Delapril is used in the treatment of hypertension.

Delapril should not be used in people with aortic stenosis or outflow tract obstruction, in those with active or suspected kidney blood vessel disease and in pregnancy.

Delapril may give rise to the following side effects:

  • Hypotension
  • Dizziness
  • Fatigue
  • Headache
  • GI disturbances
  • Persistent dry cough
  • Other upper respiratory tract symptoms
  • Angioedema
  • Blood disorders (e.g. neutropenia and agranulocytosis)
  • Hyperkalaemia
  • Hyponatraemia
  • Skin rashes

Precautions

Delapril should be used with caution in patients with the following conditions:

  • History of idiopathic or hereditary angioedema
  • Diarrhoea
  • Water or sodium depletion
  • Peripheral vascular disease
  • Generalised atherosclerosis
  • Collagen vascular disorders (e.g. SLE, scleroderma)
  • Kidney problems
  • Lactation

 

Interactions

Delapril may interact with the following medicines:

  • Potassium sparing diuretics
  • Potassium supplements
  • Other drugs that can cause hyperkalaemia (e.g. ciclosporin, indometacin)

If you think you have overdosed, seek emergency medical help immediately

 

Available Brands:

  • Delaket
  • Pigreco
  • Adecut
  • Delakete

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