CHLORPHEN-PSEUDOEPH-IBUPROFEN

Do not use this drug if:

• You are allergic to any ingredient in Chlorpheniramine, Pseudoephedrine and ibuprofen or if you have any other allergies.
• You have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems.
• You are in the last 3 months of pregnancy.
• You have recently had or will be having bypass heart surgery.
• You are taking Sodium Oxybate (GHB) or if you have taken Furazolidone or a Monoamine Oxidase Inhibitor (MAOI) like Phenelzine within the last 14 days.

Common side effects may include:

• Upset Stomach
• Mild Heartburn
• Nausea
• Vomiting
• Bloating, Gas, Diarrhea, Constipation
• Dizziness or Headache
• Nervousness
• Flushing (Warmth, Redness, or Tingly Feeling)
• Mild Itching or Rash
• Ringing In Your Ears

Severe side effects may include:

• Severe Allergic Reaction
• Chest Pain Spreading to your Jaw or Shoulder
• Sudden Numbness or Weakness on One Side of the Body
• Slurred Speech
• Feeling Short of Breath

Precautions

Tell your doctor or pharmacist if you have any medical conditions, especially if:

• You are pregnant, planning to become pregnant, or are breast-feeding
• You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• You have allergies to the content of this drug or if you have other allergies.
• You have a history of:
  • Adrenal Gland Problems (e.g, Adrenal Gland Tumor)
  • Asthma
  • Stomach or Bowel Problems (e.g, Bleeding, Perforation, Persistent or Returning Stomach Pain or Heartburn, Ulcers)
  • Heart Problems (e.g, Heart Failure)
  • High Blood Pressure
  • Diabetes
  • Blood Disorders
  • Bleeding or Clotting Problems
  • Blood Vessel Problems
  • Stroke
  • Glaucoma or Increased Eye Pressure
  • An Enlarged Prostate or Other Prostate Problems
  • Overactive Thyroid
  • Kidney Problems and Liver Problems (e.g, Hepatitis)
  • Lupus

Interactions

Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

• Anticoagulants (eg, Warfarin), Aspirin, Corticosteroids (eg, Prednisone), Heparin, Or Selective Serotonin Reuptake Inhibitors (SSRIs) (eg, Fluoxetine)

-The risk of stomach bleeding may be increased.

• Beta-blockers (eg, Propranolol), Catechol-O-Methyltransferase (COMT) inhibitors (eg, Tolcapone), Furazolidone, Indomethacin, Isoniazid, MAOIs (eg, Phenelzine), Probenecid, or Tricyclic Antidepressants (eg, Amitriptyline)

– They may increase the risk of chlorpheniramine/pseudoephedrine/ibuprofen’s side effects

• Bromocriptine, Cyclosporine, Hydantoins (eg, Phenytoin), Lithium, Methotrexate, or Quinolones (eg, Ciprofloxacin)

-The risk of their side effects may be increased by chlorpheniramine, pseudoephedrine and ibuprofen

• Angiotensin-Converting Enzyme (ACE)Inhibitors (eg, Enalapril) Diuretics (eg, Furosemide, Hydrochlorothiazide), Guanadrel, Guanethidine, Mecamylamine, Methyldopa, or Reserpine

-Their effectiveness may be decreased by chlorpheniramine/pseudoephedrine/ibuprofen

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms may include:

• Blurred Vision
• Confusion
• Hallucinations
• Seizures
• Severe Dizziness, Lightheadedness or Headache
• Severe Drowsiness
• Severe Nausea or Stomach Pain
• Slow or Troubled Breathing
• Unusual Bleeding or Bruising
• Unusually Fast, Slow, or Irregular Heartbeat
• Vomit That Looks Like Coffee Grounds