COMMON BRAND NAME(S): Cedax
GENERIC NAME(S): CEFTIBUTEN
Description: Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many β-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gram negative bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Absorption: Rapidly absorbed from the GI tract after oral admin.
Distribution: 65-77% bound to plasma proteins.
Excretion: Plasma half-life: 2.0-2.3 hr; prolonged in renal impairment. Mainly in the urine and feces.