BUROSUMAB

Burosumab is a recombinant human monoclonal antibody (IgG1) that sticks to and inhibits the function of fibroblast growth factor 23 (FGF23), repairing renal phosphate reabsorption and boosting serum 1,25-dihydroxyvitamin D concentrations.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Burosumab is used in the following conditions:

Fibroblast growth factor 23 (FGF23)-related hypophosphatemia in tumour-induced osteomalacia
X-linked hypophosphatemia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Burosumab in people with the following conditions:

Severe renal impairment or ESRD
Serum phosphorus levels within or above the normal age range
Concomitant use with active vitamin D analogues or oral phosphate

Side Effects

Burosumab may have the following side effects:

Rash
Injection site reactions
Hyperphosphatemia
Urticaria
Decreased serum vitamin D
Increased serum PTH
Constipation
Vomiting,
Restless leg syndrome (adults)
Toothache for children
Nausea
Dizziness
Dental caries
Tooth abscess or infection
Diarrhea
Back pain
Headache
Muscle spasm (adults)
Limb pain
Fever for children
Myalgia
Headache
Cough for children

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Pregnancy
Children
Lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Burosumab may interact with the following medicines:

Calcitriol
Calcimimetic agents
Calcifediol
Paricalcitol
Doxercalciferol

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If an overdose is suspected, call your health care provider immediately.

Available Brands:

Crysvita