BUPROPION HCI ORAL

GENERIC NAME(S): BUPROPION HCL

COMMON BRAND NAME(S): Wellbutrin

 

Description

  • An antidepressant
    • can help prevent suicidal thoughts/attempts and provide other important benefitsCan improve your mood and feelings of well-being
    • It may work by helping to restore the balance of certain natural chemicals (neurotransmitters) in your brain
  • For treatment of depression
  • May also be used to treat attention deficit hyperactivity disorder (ADHD)
  • Assist people quit smoking by decreasing cravings and nicotine withdrawal effects
  • Prevention of autumn-winter seasonal depression (seasonal affective disorder)
  • Treatment of bipolar disorder (depressive phase) in combination with other drugs
  • Treatment of anxiety in people with depression

How to use bupropion HCl

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this medication in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor
  • Taken by mouth; With or without food; usually three times a day or as directed by your physician;
    • If stomach upset occurs, you may take this drug with food. It is important to take your doses at least 6 hours apart or as directed by your doctor to decrease your risk of having a seizure.
  • Do not take more or less medication or take it more frequently than prescribed.
    • Overdose may increase your risk of having a seizure. Do not take more than 150 milligrams as a single dose, and do not take more than 450 milligrams per day
  • Dosage is based on medical condition and response to therapy. Your dose may be slowly increased to limit side effects such as sleeplessness, and to decrease the risk of seizures. To avoid trouble sleeping, do not take this medication too close to bedtime. Let your doctor know if sleeplessness becomes a problem.
  • Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.
  • Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.
  • It may take 4 or more weeks before you notice the full benefit of this drug. Continue to take this medication as directed by your doctor even after you feel better. Talk to your doctor if your condition does not improve or if it worsens.
  • In some individuals (especially people younger than 25), may experience new or worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.
    • Physician consult is very important regarding risks and benefits of antidepressant medication, even if treatment is not for a mental/mood condition.
  • Physician consult is required immediately if these symptoms are observed:
    • new or worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech)
  • Minor side effects (if these symptoms persist or worsen, inform your doctor)
    • Nausea, vomiting, dry mouth, headache, constipation, increased sweating, joint aches, sore throat, blurred vision, strange taste in the mouth, diarrhea, or dizziness
    • May raise blood pressure
  • Serious side effects (inform your doctor immediately)
    • Chest pain, fainting, fast/pounding/irregular heartbeat, hearing problems, ringing in the ears, severe headache, mental/mood changes (e.g., agitation, anxiety, confusion, hallucinations, memory loss), uncontrolled movements (tremor), unusual weight loss or gain
    • Muscle pain/tenderness/weakness, change in the amount of urine
    • Eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night)
    • Seizures
  • Severe allergic reactions are rare. Get immediate medical help if you notice the following:
    • Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

Precautions

  • Inform your doctor
    • Allergy to the medication or any allergies
    • Medical History, especially of:
      • seizures or conditions that increase your risk of seizures (including brain/head injury, brain tumors, arteriovenous malformation, eating disorders such as bulimia/anorexia nervosa), alcohol/drug dependence (including benzodiazepines, narcotic pain medicines, cocaine and stimulants), diabetes, heart disease (e.g., congestive heart failure, high blood pressure, recent heart attack), kidney problems, liver problems (e.g., cirrhosis), personal or family history of psychiatric disorder (e.g., bipolar/manic-depressive disorder), personal or family history of suicide thoughts/attempts, personal or family history of glaucoma (angle-closure type).
  • Should not be used if you are suddenly stopping regular use of sedatives (including benzodiazepines such as lorazepam), drugs used to treat seizures, or alcohol. Doing so may increase your risk of seizures.
  • May cause dizziness or drowsiness
    • Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Alcohol also increases your risk for breathing problems.
  • Elderly may be more sensitive to the side effects of this drug
  • During pregnancy, this medication should be used only when clearly needed. Since untreated mental/mood problems (such as depression, seasonal affective disorder, bipolar disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.
  • Consult your doctor before breast-feeding as this medication passes into breast milk and may cause unwanted effects on your baby

 

Interactions

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • Products that may interact with this medication include:
    • pimozide, tamoxifen.
  • Avoid taking MAO Inhibitors while using this drug as this may cause a serious (or fatal) drug interaction. Examples are:
    • isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine
    • Should also not be taken for two weeks before and after treatment with this medication
  • Laboratory tests that may be affected:
    • Brain scan for Parkinson’s disease
    • Urine screening for amphetamines

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Psychiatric/medical checkups or tests such as blood pressure monitoring may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and as soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

Storage

  • Room temperature
  • Do not expose to light and moisture
  • Do not store in the bathroom
  • Keep all medications away from pets and children
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so
  • Properly discard this product when it is expired or no longer needed
    • Consult your pharmacist or local waste disposal company for more details about how to safely discard your product

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