Through thyroid peroxidase inhibition, Benzylthiouracil blocks the production of thyroid hormones. It does not block the release of stored thyroid hormones, thus clinical effects are apparent only when the pre-formed hormones are depleted and concentrations of circulating hormones decline.
Benzylthiouracil is used in the treatment of hyperthyroidism.
This drug should not be given in patients with porphyria.
A side effect of any drug can be defined as the unwanted or undesired effect produced by the drug. The side effect can be minor that can be ignored or major in few medications. Side effects not only vary from drug to drug, but it also depends on the dose of the drug, the individual sensitivity of the person, brand or company which manufactures it.
If side effects overweigh the actual effect of the medicine, it may be difficult to convince the patient to take the drug. There are few patients that get specific side effects to specific drugs; in that case, a doctor replaces the drug with another. If you feel any side effect and it troubles you, do not forget to share with your healthcare practitioner.
Precautions
Reserve its use in patients who are unable to tolerate any other treatments e.g. methimazole, radioactive iodine or surgery.
Inform patient of liver failure risk and tell them to report any signs of liver dysfunction (e.g. loss of appetite, nausea, vomiting, pruritus, dark coloured urine, light coloured stools, jaundice, right upper-quadrant pain) or agranulocytosis (e.g. fever, sore throat) immediately.
Stop treatment upon seeing signs of agranulocytosis, aplastic anaemia, fever, liver injury, elevated LFT above 3 times the upper limit of normal or exfoliative dermatitis.
Regular monitoring of thyroid function and CBC is advisable. Monitor prothrombin time regularly during treatment, especially before surgical procedures.
Interactions
Benzylthiouracil may potentiate the activity of anticoagulants. Doses of β-blockers, digitalis glycosides and theophylline may need to be reduced when patient becomes euthyroid.
If you think you have used benzylthiouracil more than the recommended dose, seek medical help immediately.
Available Brand:
Basdène is a known brand for benzylthiouracil.
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