ASPIRIN + VITAMIN C

• Should not be used in patients with the following conditions:
  • Gastric or duodenal ulcers, Haemophilia, thrombocytopenia or other bleeding tendencies, patients receiving anti-coagulant treatment, Hypersensitivity to aspirin or other salicylates or ascorbic acid, severe renal impairment.
• Risk of Reye’s syndrome in children with varicella infection or influenza-like illnesses.

• Caution when used in patients with impaired renal function, severe hepatic impairment, history of GI disorders e.g. peptic ulcers, ulcerative colitis and Crohn’s disease, dyspepsia and when the patient is dehydrated.

• If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.

• Before breast-feeding, consult your physician.

Dizziness, GI irritation e.g. dyspepsia, nausea, vomiting, erosion, ulceration, haematemesis and melaena. Prolonged use of high doses of aspirin may cause anaemia, blood dyscrasia, GI haemorrhage and peptic ulceration.

If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms may include:

• Dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, fluid and electrolyte losses. CNS depression may lead to coma, CV collapse and respiratory failure. Overdosage of vitamin C may lead to diarrhoea and GI disturbances.

DRUG INTERACTIONS

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

• Products that may interact with this medication include:
  • Aspirin, probenecid, phenylbutazone or sulfinpyrazone

• Labratory tests that may be affected:
  • blood creatinine, urate (low dose aspirin) and urea and falsely decrease results for blood thyroxine, urate and urinary 5-hydroxyindoleacetic acid (with nitrosonapthol method). Urinary vanillylmandelic acid (or 4-hydroxy-3-methoxymandelic acid) levels may be falsely increased or decreased depending on the method of analysis.

STORAGE

Store below 25°C.