Aspirin is a salicylate that treats pain and reduces fever or inflammation. Caffeine is a stimulant and works by relaxing the muscle contractions in blood vessels to improve blood flow. Salicylamide have analgesic and antipyretic properties and works like an Aspirin.

This combination medication is used to treat pain and fever due to headache and muscle aches. This medication may also be used in other conditions to be determined by your doctor.

Do not use this drug:

  • If you are allergic to Aspirin. Caffeine or Salicylamide.
  • To a child or teenager who has recently had an influenza vaccine (eg, flu shot) or has recently had a flu-like illness (eg, fever, chills, sore throat), chickenpox, or any other type of viral infection
  • If you have bleeding problems such as hemophilia, von Willebrand disease, low blood platelets, or active severe bleeding

Common side effects may include:

  • Heartburn
  • nausea
  • upset stomach

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Severe Allergic Reactions (Rash; Hives; Itching; Difficulty Breathing; Tightness in the Chest; Swelling of the Mouth, Face, Lips, or Tongue)
  • Black or Bloody Stools
  • Confusion
  • Diarrhea
  • Drowsiness
  • Hearing Loss
  • Ringing in the Ears
  • Severe or Persistent Dizziness
  • Severe or Persistent Stomach Pain or Heartburn
  • Shakiness
  • Trouble Sleeping
  • Vomiting


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any content of this drug or if you have other allergies.
  • If you are pregnant or breastfeeding.
  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • If you have alcoholism or if you drink 3 or more alcohol-containing drinks every day
  • If you have recently had an influenza vaccine (eg, flu shot)
  • If you have or have recently had a flu-like illness (eg, fever, chills, sore throat), chickenpox, or any other type of viral infection
  • Your medical condition or history, especially of:
    • Asthma
    • Growths in the Nose (Nasal Polyps)
    • Diabetes
    • Gout
    • Kidney Problems
    • Liver Problems (eg, Hepatitis)
    • Persistent or Frequent Stomach Problems (eg, Heartburn, Upset Stomach, Stomach Pain)
    • Peptic Ulcers
    • Bleeding Ulcers
    • Bleeding or Clotting Problems
    • Vitamin K Deficiency
    • A Weakened Blood Vessel in the Brain (eg, Cerebral Aneurysm)
    • Stroke or Bleeding in the Brain
  • If you are a child with Kawasaki syndrome (a rare inflammation causing heart problems in children)



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Carbonic Anhydrase Inhibitors (eg, Acetazolamide)
  • Anticoagulants (eg, Warfarin)
  • Clopidogrel
  • Heparin
  • Nsaids (eg, Celecoxib, Ketorolac, Ibuprofen, Naproxen)
  • Selective Serotonin Reuptake Inhibitors (eg, Fluoxetine)
  • Quinolones (eg, Ciprofloxacin)
  • Insulin or Oral Antidiabetics (eg, Glyburide, Nateglinide)
  • Methotrexate
  • Theophylline
  • Valproic Acid
  • Probenecid
  • Sulfinpyrazone

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Agitation
  • Anxiety
  • Confusion
  • Fever
  • Hearing Loss
  • Lethargy
  • Lightheadedness
  • Muscle Twitching
  • Nausea
  • Rapid Breathing
  • Rapid or Irregular Heartbeat
  • Ringing in the Ears
  • Seizures
  • Shortness of Breath
  • Stomach Pain
  • Trouble Sleeping
  • Vomiting


Available brand/s:

  • Bayer Aspirin
  • Aspitor
  • Clopate
  • Clopivaz

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