COMMON BRAND NAME(S): None
GENERIC NAME(S): NORGESTIMATE-ETHINYL ESTRADIOL
Description: Norgestimate is a progestogen that is commonly used as the progestogenic component in combined oral contraceptives and menopausal HRT.
Pharmacokinetics:
Absorption: Largely metabolised in the GI/liver during 1st pass effect; its main active metabolite, 17-deacetylnorgestimate, reaches Cmax at approximately 2 hr after dose.
Distribution: Protein binding of 17-deacetylnorgestimate: Approximately 99%.
Excretion: Half-life of 17-deacetylnorgestimate: About 37 hr. Norgestimate metabolites are excreted via urine and faeces.