Precautions
Before taking this medication, tell your doctor or pharmacist:
- If you are allergic to promethazine or to dextromethorphan; or to any other Phenothiazines (such as Prochlorperazine); or if you have any other allergies.
- If you are to undergo any surgery or x-ray with dye.
- If you are pregnant or breastfeeding.
- If you have certain medical condition that avoid or limits you to take this drug into your diet like Diabetes and Phenylketonuria (PKU).
- Your medical history, especially of:
- Breathing Problems (such as Asthma, Emphysema, Sleep Apnea)
- Heart Problems (such as Slow or Irregular Heartbeat, Chest Pain)
- Liver Problems
- Difficulty Urinating (such as Due to an Enlarged Prostate)
- Stomach or Bowel Problems (such as Blockage, Ulcer)
- High Blood Pressure
- Diabetes
- Glaucoma
- Seizures
- Blood or Immune System Problems (such as Bone Marrow Depression)
This drug may cause dizziness, drowsiness or blurred vision. Avoid activities requiring alertness or clear vision such as driving until you are sure you can perform such activities safely. Limit the use of alcohol and certain other medications that cause drowsiness.
Older adults and children may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, mental or mood changes, constipation, fast heartbeat, trouble urinating, or blood pressure changes. For children, they may also experience excitability rather than drowsiness. Special caution must be observed to those children who have a family history of sudden infant death syndrome (SIDS), those who have a severe loss of fluid (dehydration), and those who are hard to wake up from sleep.
Interactions
Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.
Possible interactions with this drug are:
- Diphenhydramine
- Antihistamines Applied to the Skin (such as Anti-Itch Cream, Ointment, Spray)
- Metoclopramide
- Mao Inhibitors (Isocarboxazid, Methylene Blue, Moclobemide, Phenelzine, Procarbazine, Rasagiline, Selegiline, or Tranylcypromine)
- Opioid Pain or Cough Relievers (such as Codeine, Hydrocodone)
- Alcohol
- Drugs For Sleep or Anxiety (such as Alprazolam, Lorazepam, Zolpidem)
- Muscle Relaxants (such as Carisoprodol, Cyclobenzaprine)
- Other Antihistamines (such as Cetirizine, Diphenhydramine)
This product may interfere with certain lab tests such as urine pregnancy tests, skin allergy tests. Make sure laboratory personnel and all your doctors know you use this drug to avoid false results.