HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

ZAVEDOS

Zavedos is used in the following conditions:

  • Acute Myeloid Leukemia (AML): Idarubicin is often used as part of combination chemotherapy regimens for the treatment of AML, a type of cancer that affects the bone marrow and blood. It is typically administered in combination with other chemotherapy drugs to help induce remission and prevent the growth of cancer cells.
  • Acute Lymphoblastic Leukemia (ALL): Idarubicin may be used in combination with other chemotherapy agents to treat ALL, a cancer that affects the lymphocytes, a type of white blood cell. It is primarily used in cases where other treatments have not been effective.
  • Other Cancers: Idarubicin may also be used in the treatment of other types of cancers, such as non-Hodgkin’s lymphoma and sarcomas. However, its use in these conditions is less common compared to AML and ALL.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Zavedos in people with the following conditions:

  • Hypersensitivity: Idarubicin should not be used in individuals who have a known hypersensitivity or allergic reaction to idarubicin or any of its components. Allergic reactions can range from mild skin reactions to severe anaphylaxis, a potentially life-threatening allergic reaction.
  • Severe liver dysfunction: Idarubicin is primarily metabolized by the liver, so individuals with severe liver dysfunction may not be able to properly metabolize the medication. Therefore, it is contraindicated in patients with severe liver impairment.
  • Severe bone marrow suppression: Idarubicin can cause suppression of bone marrow function, resulting in decreased production of blood cells. Therefore, it is contraindicated in individuals with severe bone marrow suppression, such as those with severely low levels of red or white blood cells or platelets.
  • Pregnancy and breastfeeding: Idarubicin is classified as a pregnancy category D drug, meaning it may cause harm to a developing fetus. It is contraindicated during pregnancy unless the potential benefits outweigh the risks. Idarubicin is also excreted in breast milk and can harm nursing infants, so breastfeeding is contraindicated during treatment.
  • Vaccinations: Live virus vaccines should be avoided during treatment with idarubicin, as it may interfere with the body’s response to the vaccine.

Zavedos may have the following side effects:

  • Nausea and vomiting: These are common side effects of idarubicin treatment. Your healthcare professional may prescribe anti-nausea medications to help manage these symptoms.
  • Hair loss: Idarubicin can cause temporary hair loss. Hair usually grows back once treatment is completed, but it may have a different texture or color.
  • Fatigue: Feeling tired or fatigued is a common side effect of idarubicin. It is important to listen to your body and rest when needed.
  • Low blood cell counts: Idarubicin can temporarily decrease the number of red blood cells, white blood cells, and platelets in your body. This can lead to anemia (low red blood cell count), increased risk of infections (low white blood cell count), and bleeding or bruising (low platelet count).
  • Mouth sores: Some individuals may develop mouth sores or ulcers during treatment. Maintaining good oral hygiene and using mouthwashes as recommended by your healthcare professional can help manage this side effect.
  • Increased risk of infections: Idarubicin can weaken the immune system, making you more susceptible to infections. It is important to take precautions to minimize the risk of exposure to viruses, bacteria, and other infectious agents.
  • Cardiac toxicity: Idarubicin can have an impact on the heart, and in rare cases, it may cause heart-related side effects. Your healthcare professional will monitor your heart function closely during treatment.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Medical history: Inform your healthcare professional about your complete medical history, including any previous treatments, surgeries, or existing medical conditions. This information will help them determine if idarubicin is suitable for you and if any adjustments need to be made to your treatment plan.
  • Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, inform your healthcare professional. Idarubicin can cause harm to a developing fetus and may be excreted in breast milk. It is important to discuss the potential risks and benefits with your healthcare professional.
  • Blood tests: Regular blood tests will be conducted to monitor your blood cell counts and overall health. This is important to ensure that your body is tolerating idarubicin and to detect any potential complications, such as bone marrow suppression.
  • Infections: Idarubicin can lower your immune system’s ability to fight infections. Take precautions to minimize your risk of exposure to infectious agents, such as avoiding close contact with sick individuals and practicing good hygiene habits.
  • Vaccinations: It is generally advised to avoid live virus vaccines while receiving idarubicin, as it may interfere with the body’s response to the vaccine. Consult your healthcare professional for guidance on vaccinations.
  • Cardiac monitoring: Idarubicin can have an impact on the heart, and in rare cases, it may cause heart-related side effects. Your healthcare professional will closely monitor your heart function throughout treatment. Inform them if you have a history of heart disease or any cardiac conditions.
  • Medication interactions: Inform your healthcare professional about any medications, supplements, or herbal products you are currently taking. Some medications may interact with idarubicin, affecting its effectiveness or increasing the risk of side effects.
  • Fertility: Idarubicin may affect fertility in both men and women. If you are concerned about fertility preservation, discuss this with your healthcare professional before starting treatment.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Zavedos may interact with the following medicines:

  • Medications that affect the heart: Idarubicin can have an impact on the heart, and combining it with other medications that also affect the heart can increase the risk of cardiac side effects. Examples include beta-blockers, calcium channel blockers, and certain antiarrhythmic drugs. Your healthcare professional will closely monitor your heart function during treatment.
  • Vaccines: Idarubicin may weaken the body’s response to live virus vaccines. It is generally recommended to avoid live vaccines while receiving idarubicin. Discuss with your healthcare professional about the appropriate timing for vaccinations.
  • Medications that suppress the immune system: Idarubicin can lower the immune system’s ability to fight infections. Taking other medications that also suppress the immune system, such as corticosteroids or immunosuppressants, may further increase the risk of infections. Your healthcare professional will consider these factors when managing your treatment.
  • Medications that affect blood cell counts: Idarubicin can temporarily decrease the number of red blood cells, white blood cells, and platelets in your body. Taking other medications that also affect blood cell counts, such as certain antibiotics or antiviral drugs, may further contribute to blood-related side effects. Your healthcare professional will monitor your blood cell counts closely.
  • Medications that interact with liver enzymes: Idarubicin is metabolized in the liver by certain enzymes. Taking other medications that induce or inhibit these enzymes can affect the metabolism and effectiveness of idarubicin. Examples include certain antibiotics, antifungal drugs, and antiepileptic medications. Your healthcare professional will consider these interactions when prescribing medications.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

  • Zavedos

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