ZARZIO

Do not use Zarzio in people with the following conditions:

• Allergy: Filgrastim should not be used in individuals who have a known hypersensitivity or allergic reaction to filgrastim or any of its components. Allergic reactions can range from mild symptoms like rash or itching to severe reactions like difficulty breathing or anaphylaxis.
• Myeloid Leukemia: Filgrastim is contraindicated in patients with myeloid leukemia whose cancer cells are primarily of the myeloid lineage. This is because filgrastim can stimulate the growth of myeloid leukemia cells and worsen the condition.
• Hypersensitivity to E. coli-derived Proteins: Filgrastim is produced using recombinant DNA technology in E. coli bacteria. Individuals with known hypersensitivity to E. coli-derived proteins should avoid using filgrastim.
• Patients Receiving Cytotoxic Chemotherapy: In patients receiving cytotoxic chemotherapy, filgrastim should not be administered within 24 hours before or after chemotherapy, as it may interfere with the effectiveness of the chemotherapy. Your healthcare professional will determine the appropriate timing for filgrastim administration based on your specific treatment plan and medical condition.
• Patients with Sickle Cell Disease: Filgrastim should be used with caution in patients with sickle cell disease, as it may increase the risk of sickle cell crisis. Close monitoring is necessary if filgrastim is prescribed in such cases.

Zarzio may have the following side effects:

• Bone pain: One of the most frequently reported side effects of filgrastim is bone pain. This pain is usually felt in the lower back, hips, and thighs. It can be managed with over-the-counter pain relievers under the guidance of a healthcare professional.
• Injection site reactions: Filgrastim is typically administered through injection. Some individuals may experience redness, swelling, or tenderness at the injection site. These reactions are usually mild and temporary.
• Headache: Headaches are another common side effect of filgrastim. These headaches are typically mild and can be relieved with over-the-counter pain medications.
• Nausea and vomiting: Some individuals may experience nausea or vomiting while using filgrastim. Your healthcare professional may prescribe anti-nausea medications to help manage these symptoms.
• Fatigue: Filgrastim may cause feelings of fatigue or tiredness. It is important to get enough rest and practice self-care while undergoing treatment.
• Fever: Filgrastim can sometimes cause a low-grade fever. It is important to monitor your temperature and consult with your healthcare professional if you experience a persistent or high-grade fever.
• Allergic reactions: While rare, allergic reactions to filgrastim can occur. Symptoms may include rash, itching, swelling, difficulty breathing, or dizziness. If you experience any signs of an allergic reaction, seek immediate medical attention.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Medical history: Inform your healthcare professional about your complete medical history, including any pre-existing conditions, allergies, or ongoing medications. This information will help them determine if filgrastim is suitable for you and if any adjustments need to be made.
• Infections: Filgrastim is used to stimulate the production of white blood cells, which can increase the risk of infections. If you develop signs of infection such as fever, chills, sore throat, or cough, contact your healthcare professional immediately.
• Pregnancy and breastfeeding: If you are pregnant or planning to become pregnant, discuss the risks and benefits of using filgrastim with your healthcare professional. It is also important to inform your healthcare professional if you are breastfeeding, as it is not known whether filgrastim passes into breast milk.
• Driving and operating machinery: Filgrastim is not known to impair your ability to drive or operate machinery. However, if you experience any side effects that affect your alertness or coordination, it is advisable to avoid such activities until you feel comfortable and safe.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Zarzio may interact with the following medicines:

• Chemotherapy drugs: Filgrastim is often used in conjunction with chemotherapy to stimulate the production of white blood cells. However, certain chemotherapy drugs may interact with filgrastim, potentially affecting its effectiveness or increasing the risk of side effects. Your healthcare professional will carefully monitor your treatment regimen to ensure the best outcomes.
• Lithium: Filgrastim may increase the blood levels of lithium, a medication used to treat bipolar disorder. This can potentially lead to lithium toxicity. If you are taking lithium, your healthcare professional will closely monitor your lithium levels and adjust the dosage if needed.
• Corticosteroids: Concurrent use of corticosteroids, such as prednisone, with filgrastim may reduce the effectiveness of filgrastim. Your healthcare professional will consider this interaction when developing your treatment plan.
• Nonsteroidal anti-inflammatory drugs (NSAIDs): Some NSAIDs, like ibuprofen or aspirin, may increase the risk of bleeding when used with filgrastim. It is important to inform your healthcare professional if you are taking NSAIDs so they can monitor you closely for signs of bleeding.
• Other medications: There may be other medications that can interact with filgrastim, so it is crucial to disclose your complete medication list to your healthcare professional. They will assess potential interactions and adjust your treatment plan accordingly.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Zarzio