UROKINASE

Urokinase is an enzyme derived from human urine that activates plasmin from plasminogen. The converted plasmin which is a proteolytic enzyme has fibrinolytic activity but has no specific thrombolytic property as it interacts with unbound and bound fibrin plasminogen.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Urokinase is used in the following conditions:

Deep vein thrombosis
Pulmonary embolism
Acute myocardial infarction
Peripheral arterial thromboembolism
Clearance of occluded catheters and shunts
Breakdown of clots in hyphema

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Urokinase in people with the following conditions:
- Active internal bleeding
- History of cerebrovascular accident
- Recent (within 2 months) trauma of any kind including surgery
- Aneurysm
- Known bleeding diathesis
- Severe uncontrolled hypertension
- Recent history of peptic ulcer disease
- Esophageal varices
- Ulcerative colitis or other bleeding GI lesions
- Pancreatitis
- Subacute bacterial endocarditis
- Coagulation defects including those due to liver or kidney disease after recent surgery
- Childbirth or trauma
- Increased risk of cerebral bleeding e.g. recent stroke or cerebral neoplasm
- Pregnancy
Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Side Effects

Urokinase may have the following side effects:

Bleeding
Pyrexia
Haematuria
Thromboembolic episodes
Hypersensitivity reactions

Potentially Fatal: Severe bleeding, anaphylaxis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Possibility of left heart thrombus
Subacute bacterial endocarditis
Coagulation defects
Cerebrovascular disease
Diabetic retinopathy
Any conditions in which bleeding could be dangerous

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Reduced thrombolytic effect when given again some time later due to development of high levels of antibodies.

Potentially Fatal:

Platelet inhibitors eg, aspirin and indomethacin can potentiate the action of urokinase and cause haemorrhage.
Heparin and oral anticoagulants may increase risk of bleeding.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Signs of overdose may include the following:

Haemorrhage

Seek medical help immediately.

Available Brands:

Kinlytic
Abbokinase
Abbokinase Open-Cath