ODASYL

Do not use Odasyl in people with the following conditions:

• Allergy: Amlodipine should not be used in individuals who are allergic to amlodipine or any other components of the medication.
• Severe aortic stenosis: Amlodipine is contraindicated in patients with severe aortic stenosis, a condition where the aortic valve narrows, as it can further obstruct blood flow and potentially worsen the condition.
• Hypotension: Amlodipine should be used with caution in individuals with low blood pressure (hypotension). If blood pressure is already low, amlodipine may further decrease blood pressure and cause symptoms such as dizziness, lightheadedness, or fainting.
• Liver disease: Amlodipine is primarily metabolized by the liver, so it should be used with caution in patients with liver disease. Dose adjustments may be necessary in such cases.
• Pregnancy and breastfeeding: Amlodipine is generally considered safe to use during pregnancy and breastfeeding. However, it is always important to consult with a healthcare provider before taking any medication during pregnancy or while breastfeeding to assess the potential risks and benefits.

Odasyl may have the following side effects:

• Swelling: Amlodipine may cause swelling in the ankles, feet, or hands due to fluid retention. This is known as peripheral edema.
• Flushing: Some individuals may experience facial flushing or a feeling of warmth due to the dilation of blood vessels.
• Dizziness: Amlodipine can occasionally cause dizziness or lightheadedness, especially when standing up quickly. It is important to get up slowly to minimize this effect.
• Headache: Headaches are a common side effect of amlodipine, but they usually subside with time.
• Fatigue: Amlodipine may cause feelings of tiredness or fatigue in some individuals.
• Nausea and stomach discomfort: Amlodipine can occasionally cause gastrointestinal symptoms such as nausea, stomach pain, or indigestion.
• Fluctuations in blood pressure: Amlodipine is a medication used to lower blood pressure, but it may occasionally cause blood pressure to drop too low, leading to symptoms such as dizziness or fainting.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Blood pressure monitoring: Amlodipine is primarily used to treat high blood pressure. It’s important to regularly monitor your blood pressure to ensure it is within a safe range. Your healthcare provider will guide you on how often to check your blood pressure and what the target range should be.
• Grapefruit juice: Consuming grapefruit juice while taking amlodipine may increase the levels of the medication in your body, which can lead to an increased risk of side effects. It’s generally recommended to avoid grapefruit juice or discuss it with your healthcare provider.
• Drug interactions: Amlodipine may interact with other medications, including certain antibiotics, antifungal drugs, and HIV medications. Inform your healthcare provider about all the medications, supplements, or herbal products you are taking to avoid any potential interactions.
• Liver function: Amlodipine is primarily metabolized in the liver, so it’s important to monitor liver function in individuals with liver disease or impairment. Your healthcare provider may consider dose adjustments if necessary.
• Pregnancy and breastfeeding: If you are pregnant or planning to become pregnant, it is important to discuss the risks and benefits of using amlodipine with your healthcare provider. The medication is generally considered safe to use during pregnancy, but proper monitoring is crucial. Amlodipine can be used during breastfeeding, but it’s important to consult with your healthcare provider to assess any potential risks.
• Allergy history: Inform your healthcare provider if you have a history of allergic reactions to amlodipine or any other medications. They will determine if amlodipine is safe for you or if an alternative medication should be considered.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Odasyl may interact with the following medicines:

• CYP3A4 inhibitors: Amlodipine is metabolized by the liver enzyme CYP3A4. Taking amlodipine with medications that inhibit this enzyme, such as certain antibiotics (e.g., clarithromycin, erythromycin), antifungal drugs (e.g., ketoconazole, itraconazole), or protease inhibitors used to treat HIV infection (e.g., ritonavir), may increase the levels of amlodipine in your body, leading to an increased risk of side effects.
• Grapefruit juice: Consuming grapefruit juice while taking amlodipine can inhibit the same liver enzyme (CYP3A4), potentially increasing the levels of amlodipine in your bloodstream. This can also increase the risk of side effects.
• Beta-blockers: Combining amlodipine with beta-blockers (e.g., metoprolol, atenolol) can have an additive effect on lowering blood pressure. Your healthcare provider may adjust the dosage of these medications to prevent excessive blood pressure lowering.
• ACE inhibitors and angiotensin receptor blockers (ARBs): Amlodipine is often combined with ACE inhibitors (e.g., lisinopril, enalapril) or ARBs (e.g., losartan, valsartan) to treat high blood pressure. These combinations can lead to further blood pressure reduction, but close monitoring is required to prevent excessive lowering.
• Nonsteroidal anti-inflammatory drugs (NSAIDs): Some NSAIDs, including ibuprofen and naproxen, can reduce the antihypertensive effect of amlodipine. It’s advisable to use caution when taking these medications together and consult with your healthcare provider if needed.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.
This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Odasyl