AMLODIPINE

Bivalirudin

Amlodipine is an anti-hypertensive drug that relaxes peripheral and heart and blood vessels smooth muscles. It produces vasodilation of the blood vessels of the heart by inhibiting the entry of calcium ions into the slow channels or voltage-gated channels of the vascular smooth muscle and heart muscle. It increases oxygen delivery in heart tissues among patients with angina.

Amlodipine is used to treat stable angina, hypertension and Prinzmetal’s angina

Amlodipine should not be used by patients with the following conditions:

  • Severe hypotension
  • Shock (including cardiogenic shock)
  • Obstruction of the outflow tract of the left ventricle (example aortic stenosis)
  • Hemodynamically unstable heart failure after heart attacks

Amlodipine may bring about some side effects:

  • Somnolence
  • Dizziness
  • Headache
  • Ankle swelling
  • Edema
  • Flushing
  • Fatigue
  • Palpitations
  • Abdominal pain
  • Nausea
  • Confusion (rare)
  • Rash
  • Gingival hyperplasia
  • Muscle cramps
  • Dyspnea

Precautions

Special precautions should be observed in patients with the following conditions:

  • Patients with heart failure
  • Liver and kidney impairment
  • Elderly
  • Pregnancy
  • Lactation

 

Interactions

Amlodipine may interact with the following medicines:

  • CYP3A4 inhibitors (example azole antifungals, ritonavir)
  • Simvastatin
  • Ciclosporin
  • Conivaptan

Symptoms of Amlodipine include excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia.

Seek medical help immediately.

Available Brands:

Aforbes, Amalvex, Ambloc, Amlix, Amlocor, Amlodac, Amlokard, Amlonex, Actapin, Alodine, Amaday, Ambes, Ambesyl, Amcal, Amlodia, Amlomed, Amlong

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