Except at larger dosages, metoprolol competes for 1- receptors and has little to no impact on 2- receptors. It has no intrinsic sympathomimetic or membrane-stabilizing properties. The thiazide diuretic hydrochlorothiazide inhibits sodium reabsorption in the distal tubules, resulting in increased sodium, water, potassium, and hydrogen ions excretion.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Metoprolol + Hydrochlorothiazide is used in the following conditions:

  • Hypertension

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Metoprolol + Hydrochlorothiazide in people with the following conditions:

  • 2nd- or 3rd-degree atrioventricular block
  • Sinus bradycardia
  • Sick sinus syndrome (without pacemaker)
  • Cardiogenic shock
  • Overt cardiac failure
  • Anuria
  • Severe peripheral arterial circulatory disorders (conventional tab) 

Metoprolol + Hydrochlorothiazide may have the following side effects:

  • Cardiac failure
  • Photosensitivity
  • Non-melanoma skin cancer (long-term use)
  • Bradycardia
  • Sinus pause
  • Heart block
  • Cardiac arrest
  • Gout
  • Hyperuricemia
  • Hypokalemia
  • Hypochloremic alkalosis
  • Ypomagnesemia
  • Hyponatremia
  • Azotemia
  • Acute transient myopia
  • Acute angle-closure glaucoma
  • Exacerbated angina pectoris
  • Myocardial infarction (abrupt withdrawal)
  • New-onset or exacerbation of systemic lupus erythematosus (SLE)
  • Arterial insufficiency
  • Increased cholesterol and triglyceride levels
  • Bronchospasm
  • Worsening of psoriasis
  • Agranulocytosis
  • Aplastic anemia
  • Leucopenia
  • Thrombocytopenia
  • Palpitation
  • Vertigo
  • Otalgia
  • Tinnitus
  • Blurred vision
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Xerostomia
  • Pancreatitis
  • Digestive disorder
  • Fatigue
  • Flu-like symptoms
  • Cold extremities
  • Jaundice
  • Hypersensitivity reactions (including anaphylaxis)
  • Elevated liver enzymes
  • Serum bilirubin
  • Edema
  • Anorexi
  • Hyperglycemia
  • Myalgia
  • Muscle spasm
  • Drowsiness
  • Headache
  • Dizziness
  • Lethargy
  • Nightmares
  • Short-term memory loss
  • Paresthesia
  • Restlessness
  • Depression
  • Mental confusion
  • Insomnia
  • Glycosuria
  • Impotence
  • Nasopharyngitis
  • Dyspnea
  • Diaphoresis
  • Pruritus
  • Rash
  • Purpura
  • Alopecia
  • Necrotising angiitis
  • Orthostatic hypotension

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Compensated heart failure
  • Volume depletion
  • Ischemic heart disease
  • 1st-degree atrioventricular block
  • Conduction disorders
  • Peripheral vascular disease
  • Raynaud’s disease
  • Bronchospastic disease
  • Typerthyroidism
  • Diabetes mellitus
  • History of or familial predisposition to gout
  • Hypercholesterolemia
  • Myasthenia gravis
  • Untreated pheochromocytoma
  • History of severe anaphylaxis to allergens, sulfonamide or penicillin allergy
  • Hypercalcemia
  • Patient undergoing major surgery
  • Avoid abrupt withdrawal
  • Renal and hepatic impairment
  • Pregnancy
  • Lactation


Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Metoprolol + Hydrochlorothiazide may interact with the following medicines:


  • Fluoxetine
  • Paroxetine
  • Bupropion
  • Thioridazine
  • Quinidine
  • Propafenone
  • Ritonavir
  • Diphenhydramine
  • Hydroxychloroquine
  • Terbinafine
  • Cimetidine
  • Reserpine
  • Monoamine oxidase inhibitors
  • Digitalis glycoside
  • General anaesthetics
  • Epinephrine


  • Steroids
  • Adrenocorticotropic hormone (ACTH)
  • Norepinephrine
  • Tubocurarine
  • Lithium 
  • Methyldopa
  • Non-steroidal Anti-inflammatory drugs
  • Colestyramine
  • Colestipol

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.


  • Hypotension
  • Bradycardia or tachycardia
  • Shock
  • Cardiac failure
  • Confusion
  • Dizziness
  • Muscle cramps
  • Weakness
  • Paresthesia
  • Fatigue
  • Nausea
  • Vomiting
  • Thirst
  • Bronchospasm
  • Fluid and electrolyte loss
  • Hypokalemia
  • Hyponatremia
  • Hypochloremia
  • Alkalosis
  • Raised BUN
  • Polyuria
  • Oliguria
  • Anuria

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Lopressor HCT
  • Dutoprol

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