KATHREX

Do not use Kathrex in people with the following conditions:

• Hypersensitivity: Kathrex should not be used in individuals who have a known hypersensitivity or allergic reaction to sulfamethoxazole, trimethoprim, or any other component of the medication. Allergic reactions can range from mild skin rashes to severe reactions like anaphylaxis, which is a life-threatening condition.
• Severe liver or kidney disease: Kathrex is primarily eliminated from the body through the liver and kidneys. In individuals with severe liver or kidney disease, the medication may not be adequately eliminated, leading to an increased risk of toxicity. Therefore, Kathrex is contraindicated in patients with severe impairments of liver or kidney function.
• Blood disorders: Kathrex may cause certain blood disorders, such as agranulocytosis (severely decreased white blood cell count) or megaloblastic anemia (deficiency of red blood cells). Therefore, individuals with pre-existing blood disorders or a history of blood disorders should avoid using Kathrex.
• Pregnant or breastfeeding women: Kathrex is generally not recommended for use during pregnancy, especially during the first trimester, as it may pose a risk to the developing fetus. It can also pass into breast milk and may harm the nursing infant. However, in certain cases, the benefits may outweigh the risks, and a healthcare provider can provide guidance in such situations.
• Infants younger than 2 months: Kathrex is not recommended for use in infants younger than 2 months due to the potential risk of a condition called kernicterus, which is a type of brain damage caused by high levels of bilirubin.

Kathrex may have the following side effects:

• Gastrointestinal disturbances: The most common side effects of Kathrex involve the digestive system. These can include nausea, vomiting, diarrhea, and loss of appetite. Taking the medication with food or a full glass of water may help alleviate these symptoms.
• Allergic reactions: Kathrex can occasionally cause allergic reactions, ranging from mild skin rashes to more severe reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis. If you experience any signs of an allergic reaction, such as skin rash, itching, swelling, difficulty breathing, or severe dizziness, seek immediate medical attention.
• Blood disorders: Kathrex can affect blood cell production, leading to conditions such as anemia, leukopenia (low white blood cell count), or thrombocytopenia (low platelet count). Symptoms may include fatigue, weakness, pale skin, easy bruising or bleeding, or increased susceptibility to infections. Regular blood tests may be conducted to monitor blood cell counts during treatment.
• Skin reactions: Kathrex can sometimes cause skin reactions, such as photosensitivity (increased sensitivity to sunlight), rash, or itching. It is important to use sun protection measures, such as sunscreen and protective clothing, while taking this medication.
• Kidney and liver problems: Kathrex can affect kidney function, leading to increased levels of creatinine in the blood. In some cases, it can also cause liver damage. It is important to monitor kidney and liver function while taking Kathrex, especially in individuals with pre-existing kidney or liver conditions.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Allergic reactions: If you have a known allergy to sulfamethoxazole, trimethoprim, or any other sulfonamide medications, you should avoid using Kathrex. It’s important to inform your healthcare provider of any allergies you may have before starting the medication.
• Renal impairment: Kathrex is primarily eliminated from the body through the kidneys. If you have impaired kidney function, your healthcare provider may need to adjust the dosage of Kathrex or choose an alternative treatment option. Regular monitoring of kidney function may be necessary during treatment.
• Hepatic impairment: Kathrex is metabolized in the liver. If you have liver disease or impairment, your healthcare provider may need to adjust the dosage of Kathrex or choose an alternative treatment option. Regular monitoring of liver function may be necessary during treatment.
• Folate deficiency: Kathrex can interfere with the body’s ability to utilize folate (a type of vitamin B). This can lead to folate deficiency. Your healthcare provider may recommend monitoring your folate levels or prescribing folate supplementation if necessary.
• Pregnancy and breastfeeding: Kathrex is generally not recommended during pregnancy, especially during the first trimester, as it may pose risks to the developing fetus. It can also pass into breast milk and may harm the nursing infant. However, in certain cases, the benefits may outweigh the risks, and a healthcare provider can provide guidance in such situations.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Kathrex may interact with the following medicines:

• Warfarin and other blood thinners: Kathrex can increase the effects of blood thinners, increasing the risk of bleeding. Close monitoring of blood clotting parameters is necessary if these medications are used together.
• Oral hypoglycemic agents and insulin: Kathrex can enhance the effects of certain antidiabetic medications, leading to low blood sugar levels (hypoglycemia). Regular monitoring of blood sugar levels is recommended, and dosage adjustments may be necessary.
• Methotrexate: Kathrex can increase the levels of methotrexate in the body, potentially leading to toxic effects. Close monitoring of methotrexate levels and adjustment of the dosage may be required.
• ACE inhibitors and angiotensin receptor blockers (ARBs): Kathrex can increase the risk of high potassium levels in the blood (hyperkalemia) when used with these medications. Regular monitoring of potassium levels is important.
• Diuretics: Kathrex can enhance the effects of certain diuretics, increasing the risk of dehydration and electrolyte imbalances. Close monitoring of fluid and electrolyte balance is recommended.
• Other medications affecting kidney function: Kathrex can interact with other medications that affect kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and certain antiviral medications. This can increase the risk of kidney damage. Close monitoring of kidney function is important in such cases.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Co-trimoxazole