Efexor XR is used in the following conditions:

  • Major Depressive Disorder: Venlafaxine is commonly prescribed to treat major depressive disorder (MDD). It helps to balance the levels of serotonin and norepinephrine in the brain, which are neurotransmitters associated with mood regulation.
  • Generalized Anxiety Disorder (GAD): Venlafaxine can also be used to manage symptoms of generalized anxiety disorder, which is characterized by excessive and uncontrollable worry and anxiety.
  • Panic Disorder: Venlafaxine may be prescribed for the treatment of panic disorder, a condition characterized by recurring panic attacks. It can help reduce the frequency and severity of panic attacks.
  • Social Anxiety Disorder (Social Phobia): Venlafaxine may be used to manage symptoms of social anxiety disorder, which involves intense fear or anxiety in social situations.
  • Post-Traumatic Stress Disorder (PTSD): Venlafaxine can be prescribed for the treatment of post-traumatic stress disorder, a condition that can develop after experiencing or witnessing a traumatic event.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Efexor XR in people with the following conditions:

  • Hypersensitivity: Venlafaxine should not be used in individuals who have a known hypersensitivity or allergy to the medication or any of its components. Allergic reactions can range from mild skin rashes to severe and potentially life-threatening reactions.
  • Monoamine Oxidase Inhibitors (MAOIs): Venlafaxine should not be taken within 14 days of discontinuing an MAOI therapy or starting an MAOI therapy. The combination of venlafaxine and MAOIs can lead to a serious condition called serotonin syndrome, which is characterized by symptoms such as agitation, hallucinations, rapid heartbeat, fever, and muscle stiffness.
  • Uncontrolled Narrow-Angle Glaucoma: Venlafaxine is contraindicated in individuals with uncontrolled narrow-angle glaucoma. It can increase intraocular pressure and worsen the condition.
  • Concurrent Linezolid or Methylene Blue: Venlafaxine should not be used in combination with linezolid or methylene blue due to the risk of serotonin syndrome. These medications can increase serotonin levels, and combining them with venlafaxine can lead to a potentially dangerous reaction.
  • Pregnancy and Breastfeeding: Venlafaxine should be used with caution in pregnant and breastfeeding women. It is generally recommended to discuss the potential risks and benefits with a healthcare professional before using venlafaxine during pregnancy or while breastfeeding.

Efexor XR may have the following side effects:

  • Nausea: This is one of the most commonly reported side effects of venlafaxine. It may occur during the initial stages of treatment but often improves over time.
  • Headache: Some individuals may experience headaches while taking venlafaxine. These headaches are usually mild to moderate in intensity.
  • Insomnia or Sleep Disturbances: Difficulty falling asleep, staying asleep, or experiencing changes in sleep patterns can occur with venlafaxine use.
  • Dizziness or Lightheadedness: Venlafaxine can cause feelings of dizziness or lightheadedness, especially when standing up quickly.
  • Dry Mouth: Some individuals may experience a dry mouth while taking venlafaxine. It can be helpful to drink plenty of fluids and practice good oral hygiene.
  • Sweating: Increased sweating, especially at night, is a possible side effect of venlafaxine.
  • Sexual Dysfunction: Venlafaxine may cause sexual side effects such as decreased libido, difficulty achieving orgasm, or erectile dysfunction. It is important to discuss any concerns with your healthcare provider.
  • Constipation: Venlafaxine can lead to constipation in some individuals. Maintaining a healthy diet with sufficient fiber and fluid intake may help alleviate this side effect.
  • Increased Blood Pressure: Venlafaxine has the potential to raise blood pressure, especially at higher doses. Regular blood pressure monitoring may be necessary during treatment.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Mental Health Monitoring: Venlafaxine is commonly used to treat depression, anxiety disorders, and other mental health conditions. It is important to closely monitor your mental health while taking venlafaxine. If you experience worsening depression, suicidal thoughts, or any significant changes in mood or behavior, seek immediate medical attention.
  • Serotonin Syndrome: Venlafaxine can increase serotonin levels in the brain, and in rare cases, this can lead to a potentially life-threatening condition called serotonin syndrome. Symptoms may include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. If you experience any of these symptoms, seek medical help immediately.
  • Discontinuation Syndrome: Suddenly stopping venlafaxine can result in withdrawal-like symptoms known as discontinuation syndrome. It is recommended to gradually reduce the dosage under medical supervision when discontinuing the medication.
  • Increased Blood Pressure: Venlafaxine can raise blood pressure, especially at higher doses. Regular monitoring of blood pressure is advised, particularly in individuals with pre-existing hypertension or cardiovascular conditions.
  • Liver Function: Venlafaxine is metabolized by the liver, so it is important to inform your healthcare provider if you have any liver problems. Dose adjustments may be necessary in such cases.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to discuss the potential risks and benefits of using venlafaxine with your healthcare provider. The medication can pass into breast milk and may have adverse effects on the baby.
  • Drug Interactions: Venlafaxine can interact with other medications, including MAOIs, certain antidepressants, and medications that affect serotonin levels. Inform your healthcare provider about all medications you are taking to avoid potentially harmful interactions.
  • Glaucoma: Venlafaxine may increase intraocular pressure and worsen symptoms in individuals with glaucoma. Regular eye check-ups are recommended for individuals with this condition.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Efexor XR may interact with the following medicines:

  • Monoamine Oxidase Inhibitors (MAOIs): Concurrent use of venlafaxine with MAOIs or within 14 days of discontinuing MAOIs is contraindicated, as it can lead to a potentially life-threatening condition called serotonin syndrome.
  • Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Combining venlafaxine with other medications that increase serotonin levels, such as SSRIs or SNRIs, can increase the risk of serotonin syndrome.
  • Triptans: Venlafaxine may increase the risk of serotonin syndrome when used with triptans, which are commonly used for the treatment of migraines.
  • St. John’s Wort: St. John’s Wort is an herbal supplement known for its antidepressant effects. Combining it with venlafaxine can increase the risk of serotonin syndrome.
  • Warfarin and Other Anticoagulants: Venlafaxine may affect the metabolism of warfarin and other anticoagulant medications, potentially increasing or decreasing their effectiveness. Close monitoring of INR (International Normalized Ratio) is recommended when using these medications together.
  • Antiplatelet and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Venlafaxine can increase the risk of bleeding when used with antiplatelet medications (e.g., aspirin) or NSAIDs (e.g., ibuprofen). Caution is advised, especially in individuals at higher risk of bleeding.
  • CYP2D6 Inhibitors: Venlafaxine is metabolized by the CYP2D6 enzyme. Co-administration of drugs that inhibit this enzyme, such as quinidine or fluoxetine, can increase the concentration of venlafaxine in the body.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

  • Efexor XR

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