Disopyramide, is a class Ia antiarrhythmic agent, which blocks the fast sodium channels, thus serving as a membrane stabilizing agent. It decreases the myocardial excitability and upstroke velocity, and reduces the disparity in refractory between normally perfused and infarcted myocardium. It also possesses anticholinergic, peripheral vasoconstrictive, and negative inotropic effects but no effect on alpha- or beta-adrenergic receptors.


Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Disopyramide is used in the following conditions:


This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Disopyramide in people with the following conditions:

  • Cardiogenic shock
  • Pre-existing 2nd- or 3rd-degree heart block without pacemaker
  • Bundle branch block associated with 1st-degree Atrioventricular block
  • Congenital QT prolongation
  • Severe sick sinus syndrome
  • Renal (CrCl ≤40 mL/min) impairment (modified-release)

Disopyramide may have the following side effects:

  • QT interval prolongation
  • QRS complex widening
  • Atrioventricular block
  • Bundle branch block
  • Hypotension
  • Severe heart failure
  • Cardiogenic shock
  • Nervousness
  • Headache
  • Dizziness
  • Edema
  • Chest pain
  • Bradycardia
  • Sinus block
  • Ventricular fibrillation
  • Ventricular tachycardia
  • Dry mouth
  • Abdominal pain
  • Nausea
  • Vomiting
  • Anorexia
  • Diarrhea
  • Constipation
  • Dyspnea
  • Cholestatic jaundice
  • Elevated liver enzymes
  • Dysuria
  • Acute urinary retention
  • Frequency
  • Urgency
  • Hypoglycemia
  • Thrombocytopenia
  • Agranulocytosis
  • Neutropenia
  • Diplopia
  • Blurred vision
  • Rash
  • Weight gain


Potentially fatal:

  • Torsades de pointes


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with atrial flutter
  • Benign prostatic hyperplasia
  • Hypokalemia
  • Hypomagnesemia
  • Glaucoma
  • Uncompensated congestive heart failure
  • Cardiomyopathy
  • Myasthenia gravis
  • Wolff-Parkinson-White syndrome
  • Elderly
  • Renal and hepatic impairment
  • Pregnancy
  • Lactation


Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Disopyramide may interact with the following medicines:

  • Phosphodiesterase type 5 inhibitors
  • Rifampicin
  • Phenytoin
  • Ritonavir
  • Indinavir
  • Saquinavir
  • Ciclosporin
  • Warfarin
  • Theophylline
  • Diuretics
  • Amphotericin B
  • Glucocorticoids
  • Mineralocorticoids
  • Laxatives
  • Atropine
  • Phenothiazines


Potentially fatal:

  • Tetracyclic antidepressants
  • Clarithromycin
  • Cisapride
  • Pentamidine
  • Pimozide
  • Terfenadine
  • Thioridazine


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Disopyramide more than the usual dosage, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Anticholinergic effects
  • Loss of consciousness
  • Hypotension
  • Respiratory arrest
  • Apnea
  • Cardiac conduction disturbances
  • Arrhythmias
  • QT interval prolongation
  • QRS complex widening
  • Bradycardia
  • Congestive heart failure
  • Asystole
  • Seizures


Available Brands:

  • Norpace
  • Norpace CR

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