Dimethylformamide exposure is very hazardous to one’s health, particularly if one is severely exposed, since it may cause various health issues. Dimethylformamide is a colorless, water-soluble liquid with a subtle ammonia-like odor. This organic solvent synthesizes acrylic fibers, chemicals, and pharmaceuticals; it’s also found in adhesive formulations, printing, coating, paint-stripping solvents, pigments, and textile dyes.

Furthermore, as the quantity of DMF employed every year has risen, so has concern about its possibly harmful consequences. Dimethylformamide exposure has been demonstrated in animal trials and epidemiological research to have a negative impact on the reproductive systems, kidneys, and liver in humans, with the digestive system, especially the liver, being the primary target organ. Epidemiological illness investigations on DMF-exposed employees revealed malignancy, fibrosis, cirrhosis, and hepatitis.

The following are symptoms of dimethylformamide exposure:

  • Sore throat
  • Abdominal spasms
  • Diarrhea
  • Vomiting
  • Irritation
  • Jaundice
  • Dizziness
  • Redness
  • Blurred vision
  • Liver Injury
  • Kidney damage
  • Cancer
  • Headache
  • Abdominal pain
  • Poor appetite


For frequent or possibly high dimethylformamide exposure, the following precautions should be taken before commencing work and at regular intervals after that:

  • Liver function tests

If symptoms appear or overexposure is identified, the following steps should be taken:

  • Kidney function examinations
  • Urine concentration

Any assessment must include a thorough history of previous and current symptoms and a physical examination. Medical studies that check for pre-existing harm do not replace limiting exposure.


Dimethylformamide exposure treatment is symptomatic. After high exposure, liver function must be monitored, and DMF exposure must be avoided until the patient has recovered completely.

Furthermore, although clear evidence on vulnerable subpopulations is lacking, those with pre-existing liver illnesses and pregnant women might be at increased risk while dealing with DMF. People who work with DMF might also develop an alcohol intolerance and must be advised.

First Aid:

  • Eye Contact: When it comes into contact with your eyes, rinse them with water for 15 minutes or more, raising the top and lower lids. If you are using contact lenses, take them out.
  • Skin Contact: Eliminate contaminated garments as soon as possible. Rinse the affected skin with soap and water right away.
  • Inhalation: Remove the individual from the environment. When breathing has ceased, start rescue breathing; if the cardiac movement has stopped, start CPR.

Call for medical help and transfer the patient quickly to a medical facility.

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