Watsons Health

ADEMETIONINE

Ademetionine or S-adenylyl-L-methionine is a drug that belongs to a class of drugs known as amino acids and derivatives that are used to treat diseases of the liver. It is derived from the amino acid methionine. It is not structurally stable, so the oral dosage should be in salt form as an active ingredient.

Ademetionine is used in the treatment of the following conditions:

  • Intrahepatic cholestasis in pre-cirrhotic and cirrhotic states
  • Intrahepatic cholestasis in pregnancy

Do not give Ademetionine to patients with the following conditions:

  • Hypersensitivity to the active substance or to any of the excipients
  • Genetic disorders that affects the methionine cycle and/or resulting in homocystinuria and/or hyperhomocysteinemia such as cystathionine beta-synthase deficiency
  • Vitamin B12 metabolism disorders

Ademetionine have the following side effects:

  • Headache
  • Diarrhea
  • Nausea

Precautions

Take extra caution in patients with the following medical conditions:

  • Bipolar disorder
  • Anemia
  • Liver disease
  • Pregnancy or those with potential for vitamin deficiencies due to other illnesses or eating habits
  • At risk for suicide and other serious events
  • Transient or worsening anxiety
  • Concomitant use of SSRIs, TCAs, clomipramine and herbal supplements containing tryptophan
  • Kidney impairment
  • Pregnancy
  • Lactation
  • Children
  • Elderly greater or equal to 65 years of age

Interactions

Ademetionine may interact with the following medicines:

  • Clomipramine
  • Selective serotonin reuptake inhibitors (SSRI)
  • Tricyclic antidepressants like clomipramine
  • Over-the-counter and herbal supplements containing tryptophan

If you think you have used Ademetionine more than the usual dosage, please seek medical help immediately.

Available Brands:

  • Transmetil

Related Articles

LESINURAD

Lesinurad suppresses the enzymes uric acid transporter 1 (URAT1) and organic anion carrier 4 (OAT4), which increases uric acid outflow [...]

LEMBOREXANT

Lemborexant is an orexin potent inhibitor that's competitive. It is considered to prevent the attachment of wake-promoting neurotrophins orexin A [...]

INSULIN LISPRO + INSULIN LISPRO PROTAMINE

Insulin lispro is a fast-acting human insulin alternative, whereas insulin lispro protamine is a slow-acting human insulin alternative. They both [...]