Candesartan + Hydrochlorothiazide is a prodrug of candesartan that inhibits the vasoconstrictor and aldosterone-secreting impacts of angiotensin II. It does this by specifically attaching to AT1 receptors.
Hydrochlorothiazide is a diuretic drug that acts on the first portion of the distal tubules. It enhances the discharge of sodium and chloride particles, and water, by decreasing electrolyte reabsorption from the kidney tubules.