ZILEUTON

COMMON BRAND NAME(S): Zyflo

GENERIC NAME(S): ZILEUTON

 

Description: Zileuton is a specific 5-lipoxygenase inhibitor that inhibits leukotriene formation which improves asthma symptoms.

Uses

  • Used to control long-term (chronic) asthma and help decrease the number of asthma attacks. It will not treat a sudden asthma attack.

How to use zileuton

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this medication in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor.
  • Taken by mouth; With or without food; usually four times a day or as directed by your physician.

Side Effects

Minor side effects (if these symptoms persist or worsen, inform your doctor)

  • Nausea, drowsiness, constipation, dizziness, trouble sleeping, gas, joint pain, eye redness, or vomiting.

Serious side effects (inform your doctor immediately)

  • chest pain, neck pain/stiffness, mental/mood changes (e.g., agitation, aggression, hallucinations, abnormal dreams, depression, suicidal thoughts/suicide), yellowing skin/eyes, dark urine, severe stomach/abdominal pain, unusual tiredness, flu-like symptoms (e.g., headache, fever, chills, muscle aches).

Severe allergic reactions are rare. Get immediate medical help if you notice the following:

  • rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Precautions

Precautions

  • Inform your doctor.
    • Allergy to the medication or any allergies.
    • Medical History of liver disease, alcohol use.
  • May cause dizziness or drowsiness. Limit alcohol intake.
  • Should only be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.
  • It is unknown if this drug passes into breast milk. Before breast-feeding, consult your physician.

 

Interactions

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • Products that may interact with this medication include:
    • pimozide, propranolol, theophylline, warfarin.

Overdose & Brands

If overdose is suspected, contact a poison control center or emergency room immediately.

Missed Dose: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and as soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

Storage:

  • Room temperature
  • Do not expose to light and moisture
  • Do not store in the bathroom
  • Keep all medications away from pets and children

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