ZAVICEFTA

Do not use Zavicefta in people with the following conditions:

• Known hypersensitivity: Zavicefta should not be used in individuals who have a known hypersensitivity or allergic reaction to ceftazidime, avibactam, or any other components of the medication. Allergic reactions can range from mild skin rashes to severe, life-threatening reactions.
• Severe hypersensitivity to beta-lactam antibiotics: Zavicefta should be used with caution in individuals who have a history of severe hypersensitivity reactions, such as anaphylaxis, to other beta-lactam antibiotics (e.g., penicillins, cephalosporins). Close monitoring is necessary in such cases.

Zavicefta may have the following side effects:

• Diarrhea: This is a common side effect of many antibiotics, including Zavicefta. It is usually mild and resolves on its own. However, if you experience severe or persistent diarrhea, inform your healthcare provider.
• Nausea and vomiting: Some individuals may experience nausea or vomiting while taking Zavicefta. Taking the medication with food may help reduce these symptoms.
• Headache: Headache is a relatively common side effect and is usually mild. Drinking plenty of fluids and getting adequate rest may help alleviate this symptom.
• Rash or itching: Skin reactions, such as rashes or itching, may occur in some individuals. If you develop a rash or experience severe itching, seek medical attention.
• Injection site reactions: Zavicefta is usually administered intravenously, and injection site reactions, such as pain, redness, or swelling, may occur. Inform your healthcare provider if you experience any such reactions.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Allergies: Inform your healthcare provider if you have a known allergy to ceftazidime, avibactam, or any other beta-lactam antibiotics. This information is crucial to avoid potential allergic reactions.
• Kidney function: Zavicefta is primarily eliminated through the kidneys. If you have impaired kidney function, your healthcare provider may need to adjust the dosage or frequency of administration. Make sure to disclose any pre-existing kidney conditions or any medications that may affect kidney function.
• Other medications: Inform your healthcare provider about any other medications you are taking, including prescription, over-the-counter, and herbal supplements. Certain medications may interact with Zavicefta, potentially affecting its efficacy or increasing the risk of side effects.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Zavicefta with your healthcare provider. They will evaluate the potential risks and benefits and determine if the medication is suitable for you.
• Drug-resistant infections: Zavicefta is indicated for specific types of infections caused by susceptible bacteria. It should not be used for viral infections or non-bacterial causes. Misuse or overuse of antibiotics can contribute to the development of drug-resistant infections, so it is important to use this medication only as prescribed by your healthcare provider.
• Monitoring: Your healthcare provider may need to monitor your response to treatment, including periodic blood tests, to ensure the medication is working effectively and to detect any potential side effects or complications.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Zavicefta may interact with the following medicines:

• Probenecid: Probenecid can increase the levels of ceftazidime in the body by reducing its elimination. This can potentially lead to an increased risk of side effects. Your healthcare provider may need to adjust the dosage of Zavicefta if you are taking probenecid.
• Medications that affect kidney function: Zavicefta is primarily eliminated through the kidneys. Medications that affect kidney function, such as diuretics or nonsteroidal anti-inflammatory drugs (NSAIDs), may interfere with the clearance of the medication. Your healthcare provider will consider these interactions when determining the appropriate dosage or frequency of administration.
• Anticoagulants: There have been reports of increased bleeding in patients receiving Zavicefta and anticoagulants, such as warfarin. Your healthcare provider may need to monitor your blood clotting parameters more closely if you are taking both medications.
• Vaccines: Zavicefta may decrease the effectiveness of certain vaccines. If you are receiving any vaccinations, inform your healthcare provider about your medication use to ensure appropriate immunization strategies.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Ceftazidime + avibactam