Werlhof disease, known as Immune thrombocytopenia, is a bleeding disorder caused by a lack of platelets, preventing blood clotting. A blood test can determine how many platelets you have, and most individuals benefit from medications. Although this illness can impact both children and adults, it is most commonly diagnosed in children.

When you have Werlhof disease, your blood doesn’t clot properly because of having lesser platelets (thrombocytes) than usual. When a blood vessel wall is cut, platelets clot (join together) to stop the bleeding.

Without sufficient platelets, the patient may experience bleeding within their body, beneath the skin, or on the skin. The following terms are also known as Werlhof disease: Immune thrombocytopenic purpura, Autoimmune thrombocytopenic purpura, and Idiopathic thrombocytopenic purpura.


Werlhof disease is classified into two types. They are as follows:

Acute immune thrombocytopenia. It lasts for less than six months. Typically occurs in children just after a viral infection.

Chronic immune thrombocytopenia. It lasts for more than six months. Adults are more susceptible to it than children. Women are more likely than men to be affected by this condition.


Patients may not notice any symptoms, but they may appear slowly or instantly if you do. Among the possible symptoms are:

  • Tiny reddish or purple dots on the skin that resemble a rash.
  • Purpura (purple bruises).
  • Contusion beneath the skin.
  • Blood in the urine or fecal matter.
  • Brain bleeding (rare).


In diagnosing Werlhof disease, the doctor will do a thorough physical examination, medical history to detect bleeding on or beneath the skin. Your doctor can also request blood tests to confirm the diagnosis.


If you have a minor case of Werlhof disease, you may not require treatment. If you need treatment, the doctor will look at your platelet count and how frequently you bleed.

Children who begin taking medication can recover. It may take more time for adults. Remission can happen at any time, depending on your general health and the treatment you’re receiving. It could take months, if not years, to complete.

Medication may be used in some treatments include:

  • Corticosteroids
  • Thrombopoietin receptor agonists
  • Immunosuppressive medicines
  • Immunoglobulin.
  • Rho(D) immune globulin 

Additional treatment options for immune thrombocytopenia:

  • Platelet transfusion
  • Surgery

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