COMMON BRAND NAME(S): Vfend
GENERIC NAME(S): VORICONAZOLE
Description: Voriconazole is an antifungal agent which inhibits ergosterol synthesis in fungal cell membranes, thereby killing the fungi. It has a broad spectrum of activity against all Candida species (including strains resistant to fluconazole), Aspergillus spp., Scedosporium spp., and Fusarium spp.
Absorption: Rapidly and almost completely absorbed from the GI tract. Food decreases absorption. Bioavailability: 96%. Highest concentration in the blood is 1 to 2 hour after taking.
Distribution: Diffuses in CSF. Plasma protein binding: Approx 58%.
Metabolism: Saturable metabolism. Metabolised by CYP2C19 isoenzyme to the major metabolite (inactive N-oxide), and also by CYP2C9 and CYP3A4 isoenzymes.
Excretion: Via urine (approx 80%).