Variant Creutzfeldt-Jakob disease (vCJD) is a prion disease or a form of transmissible spongiform encephalophaties, a family of few progressive neurodegenerative disorders. It affects both humans and animals. Patients with vCJD have distinguished psychiatric or frequent anxiety and depression or sensory symptoms. It delays the beginning of neurological abnormalities, such as ataxia, dementia, and myoclonus within weeks or months. This disease always leads to death.
The duration of the disease is 14 months on average. It tends to affect younger individuals aged around 28 years old. The incubation period of vCJD after foodborne exposure is about ten years. The transmission of vCJD is through the consumption of cattle products that are contaminated with the agent of BSE. A cluster of misfolded prion proteins causes variant Creutzfeldt Jakob disease. It produces disease by disseminating the abnormal conformation to healthy cellular prion protein. The altering of normal prion to abnormal prion protein from a chain reaction leads to a higher content of particular forms of protein.