Ustekinumab, a human monoclonal antibody that attaches to and blocks interleukins (IL)-12 and IL-23 cytokines. These interleukins (IL)-12 and IL-23 cytokines are responsible for anti-inflammatory and immune system reactions like CD4+ T-cell activation and differentiation and natural killer (NK) cell activation. The recombinant human monoclonal antibody Ustekinumab inhibits the progression of  interferon-inducible protein-10 (IP-10), monocyte chemotactic protein-1 (MCP-1), IL-8, and tumour necrosis factor-α (TNF-α).

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Ustekinumab is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Ustekinumab in people with the following conditions:

  • Severe or active infections (e.g. active tuberculosis)
  • Administration of live viral or live bacterial vaccines.

Ustekinumab may have the following side effects:

  • Antibody formation
  • Hypersensitivity reactions (e.g. anaphylaxis, angioedema)
  • Malignancy (e.g. multiple cutaneous squamous cell carcinoma)
  • Noninfectious pneumonia (e.g. interstitial pneumonia, eosinophilic pneumonia, cryptogenic organising pneumonia)
  • Exfoliative dermatitis (in patients with psoriasis).
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain.
  • Fever
  • Injection site reactions (erythema, pain)
  • Fatigue
  • Antibody formation
  • Influenza
  • Back pain
  • Arthralgia
  • Myalgia
  • Headache
  • Dizziness
  • Vaginal mycosis
  • Vulvovaginal candidiasis
  • Nasopharyngitis
  • Bronchitis
  • Upper respiratory tract infection
  • Sinusitis
  • Oropharyngeal pain
  • Pruritus

Potentially Fatal:

  • Serious infections (e.g. bacterial, mycobacterial, fungal, viral)
  • Reversible posterior leukoencephalopathy syndrome

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Patient with history of new/recurrent infections
  • Chronic
  • Latent or localised infection
  • Underlying conditions that may predispose to infection (e.g. diabetes mellitus)
  • IL-12 or -23 genetic deficiency
  • History of malignancy
  • Prolonged immunosuppression
  • PUVA treatment
  • Undergoing allergen immunotherapy, or phototherapy
  • Children
  • Pregnancy and lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Ustekinumab may interact with the following medicines:

  • Live vaccines.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

If an overdose is suspected call your healthcare provider immediately.

Available Brands:

  • Stelara

Related Articles


UsesWarningsSide EffectsPrecautionsOverdose & BrandsUses Ultravist is used in the following conditions: Radiographic Imaging: Iopromide injection is utilized to enhance the [...]


UsesWarningsSide EffectsPrecautionsOverdose & BrandsUses Ultramox is used in the following conditions: Respiratory Infections: Amoxicillin is often used to treat respiratory [...]


UsesWarningsSide EffectsPrecautionsOverdose & BrandsUses Ultraliv is used in the following conditions: Carnitine Orotate: Carnitine orotate is a combination of L-carnitine [...]